3-[5-(4-Chloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-propionyl chloride

Base Information

• Chemical Name: 3-[5-(4-Chloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-propionyl chloride
• CAS No.: 114151-49-4
• Molecular Formula: C₁₉H₁₆Cl₂N₂O₂
• Molecular Weight: 375.254
• Mol file: 114151-49-4.mol

Synonyms:3-[5-(4-Chloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-propionyl chloride

Chemical Property of 3-[5-(4-Chloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-propionyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[5-(4-Chloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-propionyl chloride

There total 3 articles about 3-[5-(4-Chloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-propionyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-[5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl]propionic acid (114150-42-4) → 3-[5-(4-Chloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-propionyl chloride (114151-49-4)

Guidance literature:

With oxalyl dichloride; In dichloromethane; for 3h; Ambient temperature;

DOI:10.1055/s-1991-26367

Reference yield:

4-methoxyphenylhydrazine hydrochloride (19501-58-7) → 3-[5-(4-Chloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-propionyl chloride (114151-49-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / NEt₃ / methanol / 6 h / Ambient temperature

2: oxalyl chloride / CH₂Cl₂ / 3 h / Ambient temperature

With oxalyl dichloride; triethylamine; In methanol; dichloromethane;

DOI:10.1055/s-1991-26367

Reference yield:

6-(4-chlorophenyl)-4,6-dioxohexanoic acid (111881-78-8) → 3-[5-(4-Chloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-propionyl chloride (114151-49-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / NEt₃ / methanol / 6 h / Ambient temperature

2: oxalyl chloride / CH₂Cl₂ / 3 h / Ambient temperature

With oxalyl dichloride; triethylamine; In methanol; dichloromethane;

DOI:10.1055/s-1991-26367

upstream raw materials:

3-[5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl]propionic acid

4-methoxyphenylhydrazine hydrochloride

6-(4-chlorophenyl)-4,6-dioxohexanoic acid

Downstream raw materials:

tepoxalin