114150-42-4

Basic information

• Product Name: 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]propanoic acid
• Synonyms: 1H-pyrazole-3-propanoic acid, 5-(4-chlorophenyl)-1-(4-methoxyphenyl)-; 3-[5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]propanoic acid
• CAS NO: 114150-42-4
• Molecular Formula: C₁₉H₁₇ClN₂O₃
• Molecular Weight: 356.8029
• Mol File: 114150-42-4.mol

Chemical Properties

• Boiling Point: 544.7°C at 760 mmHg
• Flash Point: 283.2°C
• Density: 1.28g/cm³
• Vapor Pressure: 1.07E-12mmHg at 25°C
• Refractive Index: 1.615
• CAS DataBase Reference: 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]propanoic acid(114150-42-4)
• EPA Substance Registry System: 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]propanoic acid(114150-42-4)

Safety Data

• Hazardous Substances Data: 114150-42-4(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 19501-58-7 4-methoxyphenylhydrazine hydrochloride 
• 111881-78-8 6-(4-chlorophenyl)-4,6-dioxohexanoic acid 
• 114149-93-8 5-(4-chlorophenyl)-3-(3-hydroxypropyl)-1-(4-methoxyphenyl)pyrazole 

Downstream Products

• 114150-91-3 3-[5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl] propyl 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl] propionate 
• 103475-41-8 tepoxalin 
• 114150-93-5 methyl 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]propionate 
• 114151-49-4 3-[5-(4-Chloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-propionyl chloride 

Relevant articles and documents

3-[5-(4-Chloro-phen-yl)-1-(4-methoxy-phen-yl)-1H-pyrazol-3-yl]propionic acid and the corresponding methyl ester

The synthesis of 3-[5-(4-chloro-phen-yl)-1-(4-methoxy-phen-yl)-1H-pyrazol- 3-yl]propionic acid, C19H17ClN2O3, (I), and its corresponding methyl ester, methyl 3-[5-(4-chloro-phen-yl)-1-(4-methoxy-phen-yl)-1H-pyrazol-3-yl]propionate, C20H19ClN2O3, (II), is

The regioselective synthesis of tepoxalin, 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl]-N-hydroxy-N-me thylpropanamide and related 1,5-diarylpyrazole anti-inflammatory agents

Tepoxalin, a potent anti-inflammatory agent, and its analogs can be synthesized by condensing an appropriate arylhydrazine hydrochloride and a 6-aryl-4,6-dioxohexanoic acid in alcohol with a base catalyst. These diarylpyrazolylpropanoic acids can be converted to their N-methylhydroxamic acids by generating the requisite acid chloride, and allowing it to react with N-methylhydroxylamine.

1,5-Diaryl-3-substituted pyrazoles pharmaceutical compositions and use

1,5-Diaryl-3-substituted pyrazoles, a method of their preparation, compositions containing the same and methods of their use are disclosed. The pyrazoles are useful in alleviating inflammatory and cardiovascular disorders in mammals.