(R)-N-(α-methoxyphenylacetyl)-(R)-3-ethoxy-4-(methylamino)-4,5,6,7-tetrahydro-1,2-benzisoxazole

Base Information

Chemical Name:(R)-N-(α-methoxyphenylacetyl)-(R)-3-ethoxy-4-(methylamino)-4,5,6,7-tetrahydro-1,2-benzisoxazole
CAS No.:257928-47-5
Molecular Formula:C₁₉H₂₄N₂O₄
Molecular Weight:344.411
Hs Code.:

Synonyms:(R)-N-(α-methoxyphenylacetyl)-(R)-3-ethoxy-4-(methylamino)-4,5,6,7-tetrahydro-1,2-benzisoxazole

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Chemical Property of (R)-N-(α-methoxyphenylacetyl)-(R)-3-ethoxy-4-(methylamino)-4,5,6,7-tetrahydro-1,2-benzisoxazole

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Technology Process of (R)-N-(α-methoxyphenylacetyl)-(R)-3-ethoxy-4-(methylamino)-4,5,6,7-tetrahydro-1,2-benzisoxazole

There total 5 articles about (R)-N-(α-methoxyphenylacetyl)-(R)-3-ethoxy-4-(methylamino)-4,5,6,7-tetrahydro-1,2-benzisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 34713-98-9
(R)-(-)-α-methoxyphenylacetyl chloride

: 182317-08-4
(RS)-3-ethoxy-4-(methylamino)-4,5,6,7-tetrahydro-1,2-benzisoxazole

: (R)-N-(α-Methoxyphenylacetyl)-(S)-3-ethoxy-4-(methylamino)-4,5,6,7-tetrahydro-1,2-benzisoxazole

: 257928-47-5
(R)-N-(α-methoxyphenylacetyl)-(R)-3-ethoxy-4-(methylamino)-4,5,6,7-tetrahydro-1,2-benzisoxazole

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm9904452

Reference yield:

: 27772-90-3
4,5,6,7-tetrahydro-1,2-benz-3-isoxazolol

: 257928-47-5
(R)-N-(α-methoxyphenylacetyl)-(R)-3-ethoxy-4-(methylamino)-4,5,6,7-tetrahydro-1,2-benzisoxazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: K₂CO₃ / acetone / 1 h / 50 °C

1.2: 54 percent / acetone / 1.5 h / 50 °C

2.1: 71 percent / Na₂Cr₂O₇*2H₂O; HOAc; conc. H₂SO₄ / 2 h

3.1: 98 percent / NaCNBH₃; 3 Angstroem molecular sieves / ethanol; methanol / 20 h / 20 °C

4.1: ET₃N / CH₂Cl₂ / 2 h / 20 °C

With sodium dichromate; 3 A molecular sieve; sulfuric acid; sodium cyanoborohydride; potassium carbonate; acetic acid; triethylamine; In methanol; ethanol; dichloromethane; acetone; 1.1: Metallation / 1.2: Alkylation / 2.1: Oxidation / 3.1: reductive amination / 4.1: Acylation;
DOI:10.1021/jm9904452

Reference yield:

: 3966-32-3
(R)-methoxyphenylacetic acid

: 257928-47-5
(R)-N-(α-methoxyphenylacetyl)-(R)-3-ethoxy-4-(methylamino)-4,5,6,7-tetrahydro-1,2-benzisoxazole

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / CH₂Cl₂

2: ET₃N / CH₂Cl₂ / 2 h / 20 °C

With thionyl chloride; triethylamine; In dichloromethane; 1: Chlorination / 2: Acylation;
DOI:10.1021/jm9904452