1,8-bis(5-tert-butyl-3-formyl)-2-methoxyphenyloctane

Base Information

• Chemical Name: 1,8-bis(5-tert-butyl-3-formyl)-2-methoxyphenyloctane
• CAS No.: 355118-33-1
• Molecular Formula: C₃₂H₄₆O₄
• Molecular Weight: 494.715
• Mol file: 355118-33-1.mol

Synonyms:1,8-bis(5-tert-butyl-3-formyl)-2-methoxyphenyloctane

Chemical Property of 1,8-bis(5-tert-butyl-3-formyl)-2-methoxyphenyloctane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1,8-bis(5-tert-butyl-3-formyl)-2-methoxyphenyloctane

There total 3 articles about 1,8-bis(5-tert-butyl-3-formyl)-2-methoxyphenyloctane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

1,8-bis(5-tert-butyl-2-methoxyphenyl)octane (132098-48-7) → 1,8-bis(5-tert-butyl-3-formyl)-2-methoxyphenyloctane (355118-33-1)

Guidance literature:

With titanium tetrachloride; at 20 ℃; regioselective reaction;

DOI:10.1039/c7ob00400a

Reference yield: 70.0%

Dichloromethyl methyl ether (4885-02-3) + 1,8-bis(5-tert-butyl-2-methoxyphenyl)octane (132098-48-7) → 1,8-bis(5-tert-butyl-3-formyl)-2-methoxyphenyloctane (355118-33-1)

Guidance literature:

Dichloromethyl methyl ether; 1,8-bis(5-tert-butyl-2-methoxyphenyl)octane; With titanium tetrachloride; In dichloromethane; at 20 ℃; for 2h;

With water; In dichloromethane; Further stages.;

DOI:10.1039/b010205i

Reference yield:

5-tert-butyl-2-methoxyphenylmagnesium bromide → 1,8-bis(5-tert-butyl-3-formyl)-2-methoxyphenyloctane (355118-33-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 87 percent / HMPA / cuprous bromide / tetrahydrofuran / Heating

2.1: TiCl₄ / CH₂Cl₂ / 2 h / 20 °C

2.2: 70 percent / H₂₀ / CH₂Cl₂

With N,N,N,N,N,N-hexamethylphosphoric triamide; titanium tetrachloride; copper(I) bromide; In tetrahydrofuran; dichloromethane;

DOI:10.1039/b010205i

upstream raw materials:

Dichloromethyl methyl ether

1,8-bis(5-tert-butyl-2-methoxyphenyl)octane