(3R,4R)-4-((tert-butyldimethylsilyl)oxy)-5-hydroxy-3-isopropylpentyl benzoate

Base Information

Chemical Name:(3R,4R)-4-((tert-butyldimethylsilyl)oxy)-5-hydroxy-3-isopropylpentyl benzoate
CAS No.:1375478-68-4
Molecular Formula:C₂₁H₃₆O₄Si
Molecular Weight:380.6
Hs Code.:

Synonyms:(3R,4R)-4-((tert-butyldimethylsilyl)oxy)-5-hydroxy-3-isopropylpentyl benzoate

Suppliers and Price of (3R,4R)-4-((tert-butyldimethylsilyl)oxy)-5-hydroxy-3-isopropylpentyl benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4R)-4-((tert-butyldimethylsilyl)oxy)-5-hydroxy-3-isopropylpentyl benzoate

Chemical Property:

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Technology Process of (3R,4R)-4-((tert-butyldimethylsilyl)oxy)-5-hydroxy-3-isopropylpentyl benzoate

There total 7 articles about (3R,4R)-4-((tert-butyldimethylsilyl)oxy)-5-hydroxy-3-isopropylpentyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1375478-67-3
(3R,4R)-4,5-bis((tert-butyldimethylsilyl)oxy)-3-isopropylpentyl benzoate

: 1375478-68-4
(3R,4R)-4-((tert-butyldimethylsilyl)oxy)-5-hydroxy-3-isopropylpentyl benzoate

Guidance literature:: With pyridine; hydrogen fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 7h; Inert atmosphere;
DOI:10.1002/anie.201108564

Reference yield:

: 1375478-65-1
C₁₈H₂₆O₄

: 1375478-68-4
(3R,4R)-4-((tert-butyldimethylsilyl)oxy)-5-hydroxy-3-isopropylpentyl benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: water; acetic acid / 2 h / 20 - 50 °C

2: 1H-imidazole; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere

3: pyridine; hydrogen fluoride / tetrahydrofuran / 7 h / 0 - 20 °C / Inert atmosphere

With pyridine; 1H-imidazole; dmap; hydrogen fluoride; water; acetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.201108564

Reference yield:

: 1375478-63-9
ethyl (R)-3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-methylpentanoate

: 1375478-68-4
(3R,4R)-4-((tert-butyldimethylsilyl)oxy)-5-hydroxy-3-isopropylpentyl benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 2 h / 0 °C / Inert atmosphere

2: dmap; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

3: water; acetic acid / 2 h / 20 - 50 °C

4: 1H-imidazole; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere

5: pyridine; hydrogen fluoride / tetrahydrofuran / 7 h / 0 - 20 °C / Inert atmosphere

With pyridine; 1H-imidazole; dmap; lithium aluminium tetrahydride; hydrogen fluoride; water; acetic acid; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1002/anie.201108564