(E)-N-(6-Amino-1-methyl-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-(3-chloro-phenyl)-acrylamide

Base Information

Chemical Name:(E)-N-(6-Amino-1-methyl-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-(3-chloro-phenyl)-acrylamide
CAS No.:174519-06-3
Molecular Formula:C₁₇H₁₉ClN₄O₃
Molecular Weight:362.816
Hs Code.:

Synonyms:(E)-N-(6-Amino-1-methyl-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-(3-chloro-phenyl)-acrylamide

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Chemical Property of (E)-N-(6-Amino-1-methyl-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-(3-chloro-phenyl)-acrylamide

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Technology Process of (E)-N-(6-Amino-1-methyl-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-(3-chloro-phenyl)-acrylamide

There total 5 articles about (E)-N-(6-Amino-1-methyl-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-(3-chloro-phenyl)-acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 174519-00-7
6-amino-5-(3-chlorocinnamoylamino)-3-propyluracil

: 74-88-4
methyl iodide

: 174519-06-3
(E)-N-(6-Amino-1-methyl-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-(3-chloro-phenyl)-acrylamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; for 48h; Ambient temperature;
DOI:10.1055/s-1995-4082

Reference yield:

: 110472-90-7
6-amino-3-propyluracil

: 174519-06-3
(E)-N-(6-Amino-1-methyl-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-(3-chloro-phenyl)-acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1: HNO₂/H⁽¹⁺⁾

2: 98 percent / H₂ / PtO₂ / methanol / 2 h

3: 74 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / methanol; H₂O / Ambient temperature

4: 95 percent / K₂CO₃ / dimethylformamide / 48 h / Ambient temperature

With hydrogen; hydrogen cation; cis-nitrous acid; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; platinum(IV) oxide; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1055/s-1995-4082

Reference yield:

: 146830-67-3
6-amino-5-nitroso-3-propyluracil

: 174519-06-3
(E)-N-(6-Amino-1-methyl-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-(3-chloro-phenyl)-acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / H₂ / PtO₂ / methanol / 2 h

2: 74 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / methanol; H₂O / Ambient temperature

3: 95 percent / K₂CO₃ / dimethylformamide / 48 h / Ambient temperature

With hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; platinum(IV) oxide; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1055/s-1995-4082