N,6-di-tert-butyl-4-(1-(cyclohexylmethyl)-5-methyl-4-(oxetan-3-ylcarbamoyl)-1H-pyrrol-2-yl)picolinamide

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Chemical Name:N,6-di-tert-butyl-4-(1-(cyclohexylmethyl)-5-methyl-4-(oxetan-3-ylcarbamoyl)-1H-pyrrol-2-yl)picolinamide
CAS No.:1442424-65-8
Molecular Formula:C₃₀H₄₄N₄O₃
Molecular Weight:508.704
Hs Code.:

Synonyms:N,6-di-tert-butyl-4-(1-(cyclohexylmethyl)-5-methyl-4-(oxetan-3-ylcarbamoyl)-1H-pyrrol-2-yl)picolinamide

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Chemical Property of N,6-di-tert-butyl-4-(1-(cyclohexylmethyl)-5-methyl-4-(oxetan-3-ylcarbamoyl)-1H-pyrrol-2-yl)picolinamide

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Technology Process of N,6-di-tert-butyl-4-(1-(cyclohexylmethyl)-5-methyl-4-(oxetan-3-ylcarbamoyl)-1H-pyrrol-2-yl)picolinamide

There total 5 articles about N,6-di-tert-butyl-4-(1-(cyclohexylmethyl)-5-methyl-4-(oxetan-3-ylcarbamoyl)-1H-pyrrol-2-yl)picolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1442432-56-5
6-(tert-butyl)-4-(1-(cyclohexylmethyl)-5-methyl-4-(oxetan-3-ylcarbamoyl)-1H-pyrrol-2-yl)picolinic acid

: 75-64-9
tert-butylamine

: 1442424-65-8
N,6-di-tert-butyl-4-(1-(cyclohexylmethyl)-5-methyl-4-(oxetan-3-ylcarbamoyl)-1H-pyrrol-2-yl)picolinamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

Reference yield:

: 1442432-55-4
methyl 6-(tert-butyl)-4-(1-(cyclohexylmethyl)-5-methyl-4-(oxetan-3-ylcarbamoyl)-1H-pyrrol-2-yl)picolinate

: 1442424-65-8
N,6-di-tert-butyl-4-(1-(cyclohexylmethyl)-5-methyl-4-(oxetan-3-ylcarbamoyl)-1H-pyrrol-2-yl)picolinamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 60 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.33 h / 20 °C

With lithium hydroxide monohydrate; water; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1442432-65-6
5-bromo-1-(cyclohexylmethyl)-2-methyl-N-(oxetan-3-yl)-1H-pyrrole-3-carboxamide

: 1442424-65-8
N,6-di-tert-butyl-4-(1-(cyclohexylmethyl)-5-methyl-4-(oxetan-3-ylcarbamoyl)-1H-pyrrol-2-yl)picolinamide

Guidance literature:: Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride; tetrabutylammomium bromide; potassium carbonate / 1,4-dioxane; water / 1.5 h / 100 °C / Microwave irradiation; Inert atmosphere

2: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h / 60 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.33 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; lithium hydroxide monohydrate; tetrabutylammomium bromide; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;