diethyl (+/-)-3-ethyl-1-(2,4-dimethoxybenzyl)-4-oxo-2,2-azetidinedicarboxylate

Base Information

• Chemical Name: diethyl (+/-)-3-ethyl-1-(2,4-dimethoxybenzyl)-4-oxo-2,2-azetidinedicarboxylate
• CAS No.: 91922-04-2
• Molecular Formula: C₂₀H₂₇NO₇
• Molecular Weight: 393.437
• Mol file: 91922-04-2.mol

Synonyms:diethyl (+/-)-3-ethyl-1-(2,4-dimethoxybenzyl)-4-oxo-2,2-azetidinedicarboxylate

Chemical Property of diethyl (+/-)-3-ethyl-1-(2,4-dimethoxybenzyl)-4-oxo-2,2-azetidinedicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl (+/-)-3-ethyl-1-(2,4-dimethoxybenzyl)-4-oxo-2,2-azetidinedicarboxylate

There total 3 articles about diethyl (+/-)-3-ethyl-1-(2,4-dimethoxybenzyl)-4-oxo-2,2-azetidinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromobutanoyl chloride (22118-12-3) + diethyl N-(2,4-dimethoxybenzyl)-amino-malonate (81902-49-0) → diethyl (+/-)-3-ethyl-1-(2,4-dimethoxybenzyl)-4-oxo-2,2-azetidinedicarboxylate (91922-04-2)

Guidance literature:

With hydrogenchloride; triethylamine; In water; benzene;

Reference yield:

2-[(2-Bromo-butyryl)-(2,4-dimethoxy-benzyl)-amino]-malonic acid diethyl ester (102357-51-7) → diethyl (+/-)-3-ethyl-1-(2,4-dimethoxybenzyl)-4-oxo-2,2-azetidinedicarboxylate (91922-04-2)

Guidance literature:

With triethylamine; In benzene; for 6h; Yield given; Heating;

Reference yield:

diethyl N-(2,4-dimethoxybenzyl)-amino-malonate (81902-49-0) → diethyl (+/-)-3-ethyl-1-(2,4-dimethoxybenzyl)-4-oxo-2,2-azetidinedicarboxylate (91922-04-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / benzene / 1.) 30 min, 0 deg C, 2.) 30 min, RT

2: triethylamine / benzene / 6 h / Heating

With triethylamine; In benzene;

upstream raw materials:

2-[(2-Bromo-butyryl)-(2,4-dimethoxy-benzyl)-amino]-malonic acid diethyl ester

diethyl N-(2,4-dimethoxybenzyl)-amino-malonate

2-bromobutanoyl chloride