3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-4-(4-methoxy-phenylsulfanyl)-benzoyl chloride

Base Information

Chemical Name:3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-4-(4-methoxy-phenylsulfanyl)-benzoyl chloride
CAS No.:943773-94-2
Molecular Formula:C₂₄H₂₁ClN₄O₂S
Molecular Weight:464.975
Hs Code.:

Synonyms:3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-4-(4-methoxy-phenylsulfanyl)-benzoyl chloride

Suppliers and Price of 3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-4-(4-methoxy-phenylsulfanyl)-benzoyl chloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-4-(4-methoxy-phenylsulfanyl)-benzoyl chloride

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-4-(4-methoxy-phenylsulfanyl)-benzoyl chloride

There total 11 articles about 3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-4-(4-methoxy-phenylsulfanyl)-benzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-4-(4-methoxy-phenylsulfanyl)-benzoic acid

: 943773-94-2
3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-4-(4-methoxy-phenylsulfanyl)-benzoyl chloride

Guidance literature:: With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 943771-00-4
2-bromo-6-isopropyl-nicotinonitrile

: 943773-94-2
3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-4-(4-methoxy-phenylsulfanyl)-benzoyl chloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonia / ethanol / 20 h / 130 °C

2.1: toluene / 3 h / Heating / reflux

3.1: acetic acid / 1 h / 140 °C

4.1: sodium hydroxide / tetrahydrofuran; water / 3 h / 50 °C

4.2: pH 6.5

5.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

With sodium hydroxide; oxalyl dichloride; ammonia; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; dichloromethane; water; acetic acid; toluene;

Reference yield:

: 889889-20-7
3-amino-4-(4-methoxy-phenylsulfanyl)-benzoic acid methyl ester

: 943773-94-2
3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-4-(4-methoxy-phenylsulfanyl)-benzoyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / 1 h / 140 °C

2.1: sodium hydroxide / tetrahydrofuran; water / 3 h / 50 °C

2.2: pH 6.5

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

With sodium hydroxide; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; acetic acid;