(2E,7E)-(4R,5S,6R)-5-Benzyloxy-8-(tert-butyl-diphenyl-silanyloxymethyl)-6-ethyl-4-methyl-deca-2,7-dienoic acid methyl ester

Base Information

Chemical Name:(2E,7E)-(4R,5S,6R)-5-Benzyloxy-8-(tert-butyl-diphenyl-silanyloxymethyl)-6-ethyl-4-methyl-deca-2,7-dienoic acid methyl ester
CAS No.:872615-38-8
Molecular Formula:C₃₈H₅₀O₄Si
Molecular Weight:598.898
Hs Code.:

Synonyms:(2E,7E)-(4R,5S,6R)-5-Benzyloxy-8-(tert-butyl-diphenyl-silanyloxymethyl)-6-ethyl-4-methyl-deca-2,7-dienoic acid methyl ester

Suppliers and Price of (2E,7E)-(4R,5S,6R)-5-Benzyloxy-8-(tert-butyl-diphenyl-silanyloxymethyl)-6-ethyl-4-methyl-deca-2,7-dienoic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2E,7E)-(4R,5S,6R)-5-Benzyloxy-8-(tert-butyl-diphenyl-silanyloxymethyl)-6-ethyl-4-methyl-deca-2,7-dienoic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of (2E,7E)-(4R,5S,6R)-5-Benzyloxy-8-(tert-butyl-diphenyl-silanyloxymethyl)-6-ethyl-4-methyl-deca-2,7-dienoic acid methyl ester

There total 11 articles about (2E,7E)-(4R,5S,6R)-5-Benzyloxy-8-(tert-butyl-diphenyl-silanyloxymethyl)-6-ethyl-4-methyl-deca-2,7-dienoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 872615-37-7
(E)-(2S,3R,4R)-3-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-4-ethyl-2-methyl-oct-5-enal

: 21204-67-1,2605-67-6
methyl (triphenylphosphoranylidene)acetate

: 872615-38-8
(2E,7E)-(4R,5S,6R)-5-Benzyloxy-8-(tert-butyl-diphenyl-silanyloxymethyl)-6-ethyl-4-methyl-deca-2,7-dienoic acid methyl ester

Guidance literature:: In benzene;
DOI:10.1021/ol0521329

Reference yield:

: 872615-24-2
(E)-(S)-5-Methoxymethoxy-4-methyl-pent-2-enoic acid methyl ester

: 872615-38-8
(2E,7E)-(4R,5S,6R)-5-Benzyloxy-8-(tert-butyl-diphenyl-silanyloxymethyl)-6-ethyl-4-methyl-deca-2,7-dienoic acid methyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 90 percent / DIBAL-H / CH₂Cl₂ / -78 °C

2: TBHP; Ti(O-iPr)4; D-tartaric acid diethyl ester / -23 °C

3: 62 percent / CuI / diethyl ether / -50 - -40 °C

4: 52 percent / RuCl₂(PPh₃)3 / benzene

5: 76 percent / benzene / Heating

6: 84 percent / NaH / tetrahydrofuran

7: 94 percent / DIBAL-H

8: 91 percent / triethylamine

9: 84 percent / 1,3-dithiane; BF₃*Et₂O

10: 89 percent / PDC / CH₂Cl₂

11: 92 percent / benzene

With 1,3 dithiane; titanium(IV) isopropylate; tert.-butylhydroperoxide; copper(l) iodide; dipyridinium dichromate; tris(triphenylphosphine)ruthenium(II) chloride; diethyl (2S,3S)-tartrate; boron trifluoride diethyl etherate; sodium hydride; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; benzene; 5: Horner-Wittig reaction;
DOI:10.1021/ol0521329

Reference yield:

: 872615-26-4
(E)-(S)-5-Methoxymethoxy-4-methyl-pent-2-en-1-ol

: 872615-38-8
(2E,7E)-(4R,5S,6R)-5-Benzyloxy-8-(tert-butyl-diphenyl-silanyloxymethyl)-6-ethyl-4-methyl-deca-2,7-dienoic acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: TBHP; Ti(O-iPr)4; D-tartaric acid diethyl ester / -23 °C

2: 62 percent / CuI / diethyl ether / -50 - -40 °C

3: 52 percent / RuCl₂(PPh₃)3 / benzene

4: 76 percent / benzene / Heating

5: 84 percent / NaH / tetrahydrofuran

6: 94 percent / DIBAL-H

7: 91 percent / triethylamine

8: 84 percent / 1,3-dithiane; BF₃*Et₂O

9: 89 percent / PDC / CH₂Cl₂

10: 92 percent / benzene

With 1,3 dithiane; titanium(IV) isopropylate; tert.-butylhydroperoxide; copper(l) iodide; dipyridinium dichromate; tris(triphenylphosphine)ruthenium(II) chloride; diethyl (2S,3S)-tartrate; boron trifluoride diethyl etherate; sodium hydride; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; benzene; 4: Horner-Wittig reaction;
DOI:10.1021/ol0521329