N-[4-(Acetyloxy)-3-methoxyphenyl]-acetamide

Base Information

• Chemical Name: N-[4-(Acetyloxy)-3-methoxyphenyl]-acetamide
• CAS No.: 75813-77-3
• Molecular Formula: C11H13NO4
• Molecular Weight: 223.229
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID90434537
• Nikkaji Number: J607.819B
• Wikidata: Q82248988
• Mol file: 75813-77-3.mol

Synonyms:75813-77-3;N-[4-(ACETYLOXY)-3-METHOXYPHENYL]-ACETAMIDE;(4-acetamido-2-methoxyphenyl) acetate;Acetamide,N-[4-(acetyloxy)-3-methoxyphenyl]-;4-ACETAMIDO-2-METHOXYPHENYL ACETATE;N-(4-Acetoxy-3-methoxyphenyl)acetamide;SCHEMBL4785449;DTXSID90434537;AKOS030240478;AB53349;FT-0661323

Chemical Property of N-[4-(Acetyloxy)-3-methoxyphenyl]-acetamide

Chemical Property:

• Appearance/Colour: Brown solid
• Boiling Point: 371.444 °C at 760 mmHg
• Flash Point: 178.443 °C
• PSA: 64.63000
• Density: 1.212 g/cm³
• LogP: 1.65190
• Solubility.: Chloroform, Dichloromethane
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 223.08445790
• Heavy Atom Count: 16
• Complexity: 267

Purity/Quality:

98%min ^*data from raw suppliers

N-[4-(Acetyloxy)-3-methoxyphenyl]-acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=CC(=C(C=C1)OC(=O)C)OC

Technology Process of N-[4-(Acetyloxy)-3-methoxyphenyl]-acetamide

There total 9 articles about N-[4-(Acetyloxy)-3-methoxyphenyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

4-amino-2-methoxyphenol (52200-90-5) + acetic anhydride (108-24-7) → N-(4-Acetoxy-3-methoxyphenyl)acetamide (75813-77-3)

Guidance literature:

at 80 ℃; for 2h;

Reference yield:

butyl-(3-methoxy-phenyl)amine (31084-55-6) + lead(IV) tetraacetate (546-67-8) → N-(4-Acetoxy-3-methoxyphenyl)acetamide (75813-77-3) + m-methoxyacetanilide (588-16-9) + Acetic acid 4-(acetyl-butyl-amino)-2-methoxy-phenyl ester

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given; 1.) CHCl₃, RT; 2.) RT, overnight;

Reference yield:

butyl-(3-methoxy-phenyl)amine (31084-55-6) + lead(IV) tetraacetate (546-67-8) + acetic anhydride (108-24-7) → N-(4-Acetoxy-3-methoxyphenyl)acetamide (75813-77-3) + m-methoxyacetanilide (588-16-9) + Acetic acid 4-(acetyl-butyl-amino)-2-methoxy-phenyl ester

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given; 1.) CHCl₃, RT; 2.) RT, overnight;

upstream raw materials:

2-methoxy-4-nitrophenol

4-amino-2-methoxyphenol

4-amino-2-methoxyphenyl acetate

acetic anhydride

Downstream raw materials:

3-O-methyl-Acetaminophen

1-<4-Acetamino-2-methoxy-phenoxy>-5-<4-nitro-phenyl>-pentan

1-<4-Nitro-phenyl>-5-<4-amino-2-methoxy-phenoxy>-pentan