N-[2,3,5-trichloro-4-(4-hydroxy-3-isopropylphenoxy)phenyl]malonamic acid

Base Information

Chemical Name:N-[2,3,5-trichloro-4-(4-hydroxy-3-isopropylphenoxy)phenyl]malonamic acid
CAS No.:373641-60-2
Molecular Formula:C₁₈H₁₆Cl₃NO₅
Molecular Weight:432.688
Hs Code.:

Synonyms:N-[2,3,5-trichloro-4-(4-hydroxy-3-isopropylphenoxy)phenyl]malonamic acid

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Chemical Property of N-[2,3,5-trichloro-4-(4-hydroxy-3-isopropylphenoxy)phenyl]malonamic acid

Chemical Property:

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Technology Process of N-[2,3,5-trichloro-4-(4-hydroxy-3-isopropylphenoxy)phenyl]malonamic acid

There total 9 articles about N-[2,3,5-trichloro-4-(4-hydroxy-3-isopropylphenoxy)phenyl]malonamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 373641-40-8
ethyl N-[2,3,5-trichloro-4-(4-hydroxy-3-isopropylphenoxy)phenyl]malonamate

: 373641-60-2
N-[2,3,5-trichloro-4-(4-hydroxy-3-isopropylphenoxy)phenyl]malonamic acid

Guidance literature:: ethyl N-[2,3,5-trichloro-4-(4-hydroxy-3-isopropylphenoxy)phenyl]malonamate; With sodium hydroxide; In methanol; water; at 50 ℃; for 0.5h;

With hydrogenchloride; sodium chloride; In methanol; water;
DOI:10.1016/j.bmc.2012.03.056

Reference yield:

: bis(4-benzyloxy-3-isopropylphenyl)iodonium tetrafluoroborate

: 373641-60-2
N-[2,3,5-trichloro-4-(4-hydroxy-3-isopropylphenoxy)phenyl]malonamic acid

Guidance literature:: Multi-step reaction with 5 steps

1: bronze powder; triethylamine / dichloromethane / 120 h / 20 °C

2: platinum(IV) oxide; hydrogen / ethyl acetate / 2 h / 20 °C

3: pyridine / dichloromethane / 3 h / 0 - 20 °C

4: dimethylsulfide; water; trifluoroacetic acid / 20 °C

5: sodium hydroxide / methanol; water / 0.5 h / 50 °C

With pyridine; platinum(IV) oxide; bronze powder; dimethylsulfide; water; hydrogen; triethylamine; trifluoroacetic acid; sodium hydroxide; In methanol; dichloromethane; water; ethyl acetate;
DOI:10.1016/j.bmc.2012.03.056

Reference yield:

: 88-69-7
2-(1-methylethyl)phenol

: 373641-60-2
N-[2,3,5-trichloro-4-(4-hydroxy-3-isopropylphenoxy)phenyl]malonamic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / acetonitrile / 29 h / Reflux

2.1: iodine tris(trifluoroacetate); acetic anhydride; trifluoroacetic acid / 16 h / 4 °C

2.2: 0.5 h

3.1: bronze powder; triethylamine / dichloromethane / 120 h / 20 °C

4.1: platinum(IV) oxide; hydrogen / ethyl acetate / 2 h / 20 °C

5.1: pyridine / dichloromethane / 3 h / 0 - 20 °C

6.1: dimethylsulfide; water; trifluoroacetic acid / 20 °C

7.1: sodium hydroxide / methanol; water / 0.5 h / 50 °C

With pyridine; platinum(IV) oxide; bronze powder; dimethylsulfide; iodine tris(trifluoroacetate); water; hydrogen; acetic anhydride; potassium carbonate; triethylamine; trifluoroacetic acid; sodium hydroxide; In methanol; dichloromethane; water; ethyl acetate; acetonitrile;
DOI:10.1016/j.bmc.2012.03.056