(2R,3S)-allyl 2-((S)-2-((2R,3S)-2-((3S,6R)-6-((tert-butoxycarbonyl)amino)-5-mesyl-1,4-thiazepane-3-carboxamido)-3-mesylbutanamido)-4-oxo-4-(tritylamino)butanamido)-3-hydroxybutanoate

Base Information

Chemical Name:(2R,3S)-allyl 2-((S)-2-((2R,3S)-2-((3S,6R)-6-((tert-butoxycarbonyl)amino)-5-mesyl-1,4-thiazepane-3-carboxamido)-3-mesylbutanamido)-4-oxo-4-(tritylamino)butanamido)-3-hydroxybutanoate
CAS No.:1330632-80-8
Molecular Formula:C₄₇H₆₀N₆O₁₅S₃
Molecular Weight:1045.22
Hs Code.:

(2R,3S)-allyl 2-((S)-2-((2R,3S)-2-((3S,6R)-6-((tert-butoxycarbonyl)amino)-5-mesyl-1,4-thiazepane-3-carboxamido)-3-mesylbutanamido)-4-oxo-4-(tritylamino)butanamido)-3-hydroxybutanoate

Synonyms:(2R,3S)-allyl 2-((S)-2-((2R,3S)-2-((3S,6R)-6-((tert-butoxycarbonyl)amino)-5-mesyl-1,4-thiazepane-3-carboxamido)-3-mesylbutanamido)-4-oxo-4-(tritylamino)butanamido)-3-hydroxybutanoate

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Chemical Property of (2R,3S)-allyl 2-((S)-2-((2R,3S)-2-((3S,6R)-6-((tert-butoxycarbonyl)amino)-5-mesyl-1,4-thiazepane-3-carboxamido)-3-mesylbutanamido)-4-oxo-4-(tritylamino)butanamido)-3-hydroxybutanoate

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Technology Process of (2R,3S)-allyl 2-((S)-2-((2R,3S)-2-((3S,6R)-6-((tert-butoxycarbonyl)amino)-5-mesyl-1,4-thiazepane-3-carboxamido)-3-mesylbutanamido)-4-oxo-4-(tritylamino)butanamido)-3-hydroxybutanoate

There total 11 articles about (2R,3S)-allyl 2-((S)-2-((2R,3S)-2-((3S,6R)-6-((tert-butoxycarbonyl)amino)-5-mesyl-1,4-thiazepane-3-carboxamido)-3-mesylbutanamido)-4-oxo-4-(tritylamino)butanamido)-3-hydroxybutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1330632-79-5
(2R,3S)-allyl 2-((S)-2-((2R,3S)-2-((3S,6R)-6-((tert-butoxycarbonyl)amino)-5-oxo-1,4-thiazepane-3-carboxamido)-3-hydroxybutanamido)-4-oxo-4-(tritylamino)butanamido)-3-hydroxybutanoate

: 124-63-0
methanesulfonyl chloride

: 1330632-80-8
(2R,3S)-allyl 2-((S)-2-((2R,3S)-2-((3S,6R)-6-((tert-butoxycarbonyl)amino)-5-mesyl-1,4-thiazepane-3-carboxamido)-3-mesylbutanamido)-4-oxo-4-(tritylamino)butanamido)-3-hydroxybutanoate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 44h; Inert atmosphere;
DOI:10.1021/ja206017p

Reference yield:

: 1330632-74-0
(5S,8S,11S)-allyl 1-(9H-fluoren-9-yl)-5,11-bis((R)-1-hydroxyethyl)-3,6,9-trioxo-8-(2-oxo-2-(tritylamino)ethyl)-2-oxa-4,7,10-triazadodecan-12-oate

: 1330632-80-8
(2R,3S)-allyl 2-((S)-2-((2R,3S)-2-((3S,6R)-6-((tert-butoxycarbonyl)amino)-5-mesyl-1,4-thiazepane-3-carboxamido)-3-mesylbutanamido)-4-oxo-4-(tritylamino)butanamido)-3-hydroxybutanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: diethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.1: 4-methyl-morpholine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

2.2: 18 h / 20 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 44 h / 0 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; diethylamine; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja206017p

Reference yield:

: 1330632-73-9
(2S,3R)-allyl-2-((S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-4-oxo-4-(tritylamino)butanamido)-3-hydroxybutanoate

: 1330632-80-8
(2R,3S)-allyl 2-((S)-2-((2R,3S)-2-((3S,6R)-6-((tert-butoxycarbonyl)amino)-5-mesyl-1,4-thiazepane-3-carboxamido)-3-mesylbutanamido)-4-oxo-4-(tritylamino)butanamido)-3-hydroxybutanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethylamine / dichloromethane / 0 °C / Inert atmosphere

2.1: 4-methyl-morpholine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 0.25 h / 0 - 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: diethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

4.1: 4-methyl-morpholine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

4.2: 18 h / 20 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 44 h / 0 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; diethylamine; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja206017p