N-(3-methyl-benzylidene)-N'-{7-morpholin-4-yl-2-[4-(1-oxo-pentan-1-yl)piperazin-1-yl-phenyl]pyrazolo[1,5-a]pyrimidin-5-yl}hydrazine trifluoroacetate

Base Information

Chemical Name:N-(3-methyl-benzylidene)-N'-{7-morpholin-4-yl-2-[4-(1-oxo-pentan-1-yl)piperazin-1-yl-phenyl]pyrazolo[1,5-a]pyrimidin-5-yl}hydrazine trifluoroacetate
CAS No.:1232223-69-6
Molecular Formula:C₂HF₃O₂*C₃₃H₄₀N₈O₂
Molecular Weight:694.757
Hs Code.:

N-(3-methyl-benzylidene)-N'-{7-morpholin-4-yl-2-[4-(1-oxo-pentan-1-yl)piperazin-1-yl-phenyl]pyrazolo[1,5-a]pyrimidin-5-yl}hydrazine trifluoroacetate

Synonyms:N-(3-methyl-benzylidene)-N'-{7-morpholin-4-yl-2-[4-(1-oxo-pentan-1-yl)piperazin-1-yl-phenyl]pyrazolo[1,5-a]pyrimidin-5-yl}hydrazine trifluoroacetate

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Chemical Property of N-(3-methyl-benzylidene)-N'-{7-morpholin-4-yl-2-[4-(1-oxo-pentan-1-yl)piperazin-1-yl-phenyl]pyrazolo[1,5-a]pyrimidin-5-yl}hydrazine trifluoroacetate

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Technology Process of N-(3-methyl-benzylidene)-N'-{7-morpholin-4-yl-2-[4-(1-oxo-pentan-1-yl)piperazin-1-yl-phenyl]pyrazolo[1,5-a]pyrimidin-5-yl}hydrazine trifluoroacetate

There total 8 articles about N-(3-methyl-benzylidene)-N'-{7-morpholin-4-yl-2-[4-(1-oxo-pentan-1-yl)piperazin-1-yl-phenyl]pyrazolo[1,5-a]pyrimidin-5-yl}hydrazine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1232220-51-7
N-(3-methyl-benzylidene)-N'-{7-morpholin-4-yl-2-(4-piperazin-1-yl-phenyl)-pyrazolo[1,5-a]pyrimidin-5-yl}-hydrazine

: 638-29-9
n-valeryl chloride

: 1232223-69-6
N-(3-methyl-benzylidene)-N'-{7-morpholin-4-yl-2-[4-(1-oxo-pentan-1-yl)piperazin-1-yl-phenyl]pyrazolo[1,5-a]pyrimidin-5-yl}hydrazine trifluoroacetate

Guidance literature:: In dichloromethane; at 1 - 30 ℃; for 2h;

Reference yield:

: 1232223-47-0
N-(3-methylbenzylidene)-N'-{7-morpholin-4-yl-2-(4-piperazin-1-yl-phenyl)pyrazolo[1,5-a]pyrimidin-5-yl}hydrazine trifluoroacetate

: 638-29-9
n-valeryl chloride

: 1232223-69-6
N-(3-methyl-benzylidene)-N'-{7-morpholin-4-yl-2-[4-(1-oxo-pentan-1-yl)piperazin-1-yl-phenyl]pyrazolo[1,5-a]pyrimidin-5-yl}hydrazine trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.bmc.2014.03.036

Reference yield:

: 78583-82-1
3-amino-5-(4-bromophenyl)-1H-pyrazol

: 1232223-69-6
N-(3-methyl-benzylidene)-N'-{7-morpholin-4-yl-2-[4-(1-oxo-pentan-1-yl)piperazin-1-yl-phenyl]pyrazolo[1,5-a]pyrimidin-5-yl}hydrazine trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium ethanolate / ethanol / 0.83 h / 150 °C / microwave irradiation

1.2: 7 h / Cooling with ice; Reflux

2.1: 1,4-dioxane / 1 h / 1 - 30 °C

3.1: sodium t-butanolate / tri-tert-butyl phosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 0.5 h / 90 °C / Inert atmosphere

4.1: acetic acid / ethanol / 1 h / 1 - 30 °C

5.1: trifluoroacetic acid / dichloromethane / 0.33 h / 1 - 30 °C

6.1: dichloromethane / 2 h / 1 - 30 °C

With sodium ethanolate; trifluoroacetic acid; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; acetic acid; In 1,4-dioxane; ethanol; dichloromethane; toluene;