N-(3-methylbenzylidene)-N'-{7-morpholin-4-yl-2-(4-piperazin-1-yl-phenyl)pyrazolo[1,5-a]pyrimidin-5-yl}hydrazine trifluoroacetate

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Chemical Name:N-(3-methylbenzylidene)-N'-{7-morpholin-4-yl-2-(4-piperazin-1-yl-phenyl)pyrazolo[1,5-a]pyrimidin-5-yl}hydrazine trifluoroacetate
CAS No.:1232223-47-0
Molecular Formula:C₂HF₃O₂*C₂₈H₃₂N₈O
Molecular Weight:610.639
Hs Code.:

Synonyms:N-(3-methylbenzylidene)-N'-{7-morpholin-4-yl-2-(4-piperazin-1-yl-phenyl)pyrazolo[1,5-a]pyrimidin-5-yl}hydrazine trifluoroacetate

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Chemical Property of N-(3-methylbenzylidene)-N'-{7-morpholin-4-yl-2-(4-piperazin-1-yl-phenyl)pyrazolo[1,5-a]pyrimidin-5-yl}hydrazine trifluoroacetate

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Technology Process of N-(3-methylbenzylidene)-N'-{7-morpholin-4-yl-2-(4-piperazin-1-yl-phenyl)pyrazolo[1,5-a]pyrimidin-5-yl}hydrazine trifluoroacetate

There total 6 articles about N-(3-methylbenzylidene)-N'-{7-morpholin-4-yl-2-(4-piperazin-1-yl-phenyl)pyrazolo[1,5-a]pyrimidin-5-yl}hydrazine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1232220-47-1
N-[2-{4-(4-(t-butoxycarbonyl)piperazin-1-yl)phenyl}-7-morpholin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl]-N'-(3-methylbenzylidene)hydrazine

: 76-05-1
trifluoroacetic acid

: 1232223-47-0
N-(3-methylbenzylidene)-N'-{7-morpholin-4-yl-2-(4-piperazin-1-yl-phenyl)pyrazolo[1,5-a]pyrimidin-5-yl}hydrazine trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 0.333333h; Time; Inert atmosphere;
DOI:10.1016/j.bmc.2014.03.036

Reference yield:

: 1159982-81-6
2-(4-bromophenyl)-5,7-dichloropyrazolo[1,5-a]pyrimidine

: 1232223-47-0
N-(3-methylbenzylidene)-N'-{7-morpholin-4-yl-2-(4-piperazin-1-yl-phenyl)pyrazolo[1,5-a]pyrimidin-5-yl}hydrazine trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1: 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

2: sodium t-butanolate; tri-tert-butyl phosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 0.5 h / 90 °C / Inert atmosphere

3: hydrazine hydrate; potassium carbonate / ethanol / 0.58 h / 150 °C / Microwave irradiation; Inert atmosphere

4: acetic acid / ethanol / 1 h / 20 °C / Inert atmosphere

5: dichloromethane / 0.33 h / 20 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; potassium carbonate; hydrazine hydrate; acetic acid; sodium t-butanolate; In 1,4-dioxane; ethanol; dichloromethane; toluene;
DOI:10.1016/j.bmc.2014.03.036

Reference yield:

: 78583-82-1
3-amino-5-(4-bromophenyl)-1H-pyrazol

: 1232223-47-0
N-(3-methylbenzylidene)-N'-{7-morpholin-4-yl-2-(4-piperazin-1-yl-phenyl)pyrazolo[1,5-a]pyrimidin-5-yl}hydrazine trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium ethanolate / ethanol / 0.83 h / 150 °C / Microwave irradiation; Inert atmosphere

1.2: 7 h / Cooling with ice; Reflux; Inert atmosphere

2.1: 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

3.1: sodium t-butanolate; tri-tert-butyl phosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 0.5 h / 90 °C / Inert atmosphere

4.1: hydrazine hydrate; potassium carbonate / ethanol / 0.58 h / 150 °C / Microwave irradiation; Inert atmosphere

5.1: acetic acid / ethanol / 1 h / 20 °C / Inert atmosphere

6.1: dichloromethane / 0.33 h / 20 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; sodium ethanolate; potassium carbonate; hydrazine hydrate; acetic acid; sodium t-butanolate; In 1,4-dioxane; ethanol; dichloromethane; toluene;
DOI:10.1016/j.bmc.2014.03.036