3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(pyrrolidine-1-carbonyl)benzoic acid

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Chemical Name:3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(pyrrolidine-1-carbonyl)benzoic acid
CAS No.:1445788-42-0
Molecular Formula:C₂₈H₂₆N₆O₆
Molecular Weight:542.551
Hs Code.:

Synonyms:3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(pyrrolidine-1-carbonyl)benzoic acid

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Chemical Property of 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(pyrrolidine-1-carbonyl)benzoic acid

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Technology Process of 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(pyrrolidine-1-carbonyl)benzoic acid

There total 6 articles about 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(pyrrolidine-1-carbonyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₂₈N₆O₆

: 1445788-42-0
3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(pyrrolidine-1-carbonyl)benzoic acid

Guidance literature:: With water; sodium hydroxide; In methanol; at 20 ℃; for 18h;

Reference yield:

: 1374867-81-8
7-bromo-4-chloroquinoline-3-carboxamide

: 1445788-42-0
3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(pyrrolidine-1-carbonyl)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 75 °C

2: acetic acid / 18 h / 50 °C

3: sodium hydroxide; water / methanol / 18 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium carbonate; acetic acid; sodium hydroxide; In 1,4-dioxane; methanol; water;

Reference yield:

: 1955-46-0
5-nitro-1,3-benzenedicarboxylic acid, monomethyl ester

: 1445788-42-0
3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(pyrrolidine-1-carbonyl)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 4 h / 20 °C

2: hydrogen; 5%-palladium/activated carbon / methanol / 1 h / 760.05 Torr

3: acetic acid / 18 h / 50 °C

4: sodium hydroxide; water / methanol / 18 h / 20 °C

With 5%-palladium/activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; hydrogen; acetic acid; triethylamine; sodium hydroxide; In methanol; dichloromethane;