1'-benzyl-3,4-dihydro-7-methoxy-2-oxospiro

Base Information

• Chemical Name: 1'-benzyl-3,4-dihydro-7-methoxy-2-oxospiro
• CAS No.: 134697-67-9
• Molecular Formula: C₂₂H₂₅NO₂
• Molecular Weight: 335.446
• Mol file: 134697-67-9.mol

Synonyms:1'-benzyl-3,4-dihydro-7-methoxy-2-oxospiro

Chemical Property of 1'-benzyl-3,4-dihydro-7-methoxy-2-oxospiro

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1'-benzyl-3,4-dihydro-7-methoxy-2-oxospiro

There total 1 articles about 1'-benzyl-3,4-dihydro-7-methoxy-2-oxospiro which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-methoxyl-2-tetralone (4133-34-0) + N,N-bis(2-chloro-ethyl)-benzenemethanamine (55-51-6) → 1'-benzyl-3,4-dihydro-7-methoxy-2-oxospiro (134697-67-9)

Guidance literature:

With potassium tert-butylate; In dimethyl sulfoxide; tert-butyl alcohol;

DOI:10.1021/jm00089a013

Reference yield: 49.0%

1'-benzyl-3,4-dihydro-7-methoxy-2-oxospiro (134697-67-9) → 1'-benzyl-3,4-dihydro-7-hydroxyspiro(naphthalene-1-(2H),4'-piperidine) (134698-13-8) + 1'-benzyl-3,4-dihydro-7-methoxyspiro(naphthalene-1-(2H),4'-piperidine) (134697-79-3)

Guidance literature:

With potassium hydroxide; hydrazine hydrate; In diethylene glycol; for 7h; Heating;

DOI:10.1021/jm00089a013

upstream raw materials:

7-methoxyl-2-tetralone

N,N-bis(2-chloro-ethyl)-benzenemethanamine

Downstream raw materials:

1'-benzyl-3,4-dihydro-7-hydroxyspiro(naphthalene-1-(2H),4'-piperidine)

1'-benzyl-3,4-dihydro-7-methoxyspiro(naphthalene-1-(2H),4'-piperidine)