(2R)-2-[(tert-butoxy)carbonylamino]-3-indol-2-yl-N-({4-[(prop-2-enyloxycarbonylamino)methyl]phenyl}methoxy)propanamide

Base Information

Chemical Name:(2R)-2-[(tert-butoxy)carbonylamino]-3-indol-2-yl-N-({4-[(prop-2-enyloxycarbonylamino)methyl]phenyl}methoxy)propanamide
CAS No.:1173159-10-8
Molecular Formula:C₂₈H₃₄N₄O₆
Molecular Weight:522.601
Hs Code.:

Synonyms:(2R)-2-[(tert-butoxy)carbonylamino]-3-indol-2-yl-N-({4-[(prop-2-enyloxycarbonylamino)methyl]phenyl}methoxy)propanamide

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Chemical Property of (2R)-2-[(tert-butoxy)carbonylamino]-3-indol-2-yl-N-({4-[(prop-2-enyloxycarbonylamino)methyl]phenyl}methoxy)propanamide

Chemical Property:

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Technology Process of (2R)-2-[(tert-butoxy)carbonylamino]-3-indol-2-yl-N-({4-[(prop-2-enyloxycarbonylamino)methyl]phenyl}methoxy)propanamide

There total 6 articles about (2R)-2-[(tert-butoxy)carbonylamino]-3-indol-2-yl-N-({4-[(prop-2-enyloxycarbonylamino)methyl]phenyl}methoxy)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1173158-95-6
N-({4-[(aminooxy)methyl]phenyl}methyl)prop-2-enyloxycarboxamide

: 5241-64-5
Boc-D-Trp-OH

: 1173159-10-8
(2R)-2-[(tert-butoxy)carbonylamino]-3-indol-2-yl-N-({4-[(prop-2-enyloxycarbonylamino)methyl]phenyl}methoxy)propanamide

Guidance literature:: With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 22 ℃;

Reference yield:

: 1007859-08-6
N-((4-(hydroxymethyl)phenyl)methyl)prop-2-enyloxycarboxamide

: 1173159-10-8
(2R)-2-[(tert-butoxy)carbonylamino]-3-indol-2-yl-N-({4-[(prop-2-enyloxycarbonylamino)methyl]phenyl}methoxy)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,1'-azodicarbonyl-dipiperidine; triphenylphosphine / tetrahydrofuran / 23 h / 20 °C / Inert atmosphere

1.2: 5 h / 50 °C

2.1: hydrazine hydrate / methanol / 0.5 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 22 °C

With hydrazine hydrate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1173157-52-2
C₁₃H₁₅NO₄

: 1173159-10-8
(2R)-2-[(tert-butoxy)carbonylamino]-3-indol-2-yl-N-({4-[(prop-2-enyloxycarbonylamino)methyl]phenyl}methoxy)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

2.1: 1,1'-azodicarbonyl-dipiperidine; triphenylphosphine / tetrahydrofuran / 23 h / 20 °C / Inert atmosphere

2.2: 5 h / 50 °C

3.1: hydrazine hydrate / methanol / 0.5 h / Reflux

4.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 22 °C

With lithium aluminium tetrahydride; hydrazine hydrate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;