8-[(2S)-1-(3,5-difluorophenyl)pyrrolidin-2-yl]-6-(morpholine-4-carbonyl)-2-morpholino-4H-chromen-4-one

Base Information

Chemical Name:8-[(2S)-1-(3,5-difluorophenyl)pyrrolidin-2-yl]-6-(morpholine-4-carbonyl)-2-morpholino-4H-chromen-4-one
CAS No.:1403458-27-4
Molecular Formula:C₂₈H₂₉F₂N₃O₅
Molecular Weight:525.552
Hs Code.:

Synonyms:8-[(2S)-1-(3,5-difluorophenyl)pyrrolidin-2-yl]-6-(morpholine-4-carbonyl)-2-morpholino-4H-chromen-4-one

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Chemical Property of 8-[(2S)-1-(3,5-difluorophenyl)pyrrolidin-2-yl]-6-(morpholine-4-carbonyl)-2-morpholino-4H-chromen-4-one

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Technology Process of 8-[(2S)-1-(3,5-difluorophenyl)pyrrolidin-2-yl]-6-(morpholine-4-carbonyl)-2-morpholino-4H-chromen-4-one

There total 15 articles about 8-[(2S)-1-(3,5-difluorophenyl)pyrrolidin-2-yl]-6-(morpholine-4-carbonyl)-2-morpholino-4H-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 110-91-8,99108-56-2
morpholine

: 1403458-98-9
8-[(2S)-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)]-2-morpholino-4-oxo-4H-chromene-6-carboxylic acid

: 1403458-27-4
8-[(2S)-1-(3,5-difluorophenyl)pyrrolidin-2-yl]-6-(morpholine-4-carbonyl)-2-morpholino-4H-chromen-4-one

Guidance literature:: With O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; at 20 ℃; for 1.5h;

Reference yield:

: 1403458-26-3
8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-6-(morpholine-4-carbonyl)-2-morpholino-4H-chromen-4-one

: 1403458-27-4
8-[(2S)-1-(3,5-difluorophenyl)pyrrolidin-2-yl]-6-(morpholine-4-carbonyl)-2-morpholino-4H-chromen-4-one

: 1403458-28-5
8-[(2R)-1-(3,5-difluorophenyl)pyrrolidin-2-yl]-6-(morpholine-4-carbonyl)-2-morpholino-4H-chromen-4-one

Guidance literature:: With Prochrom 200mm 20jim Chiralpak AD column; In methanol; ethanol; n-heptane; Resolution of racemate;

Reference yield:

: 1296271-33-4
methyl 8-bromo-2-morpholino-4-oxo-4H-chromene-6-carboxylate

: 1403458-27-4
8-[(2S)-1-(3,5-difluorophenyl)pyrrolidin-2-yl]-6-(morpholine-4-carbonyl)-2-morpholino-4H-chromen-4-one

: 1403458-28-5
8-[(2R)-1-(3,5-difluorophenyl)pyrrolidin-2-yl]-6-(morpholine-4-carbonyl)-2-morpholino-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide; water / 5 h / 20 °C / Industry scale

1.2: 7 °C

2.1: potassium acetate / triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C / Industry scale

4.1: hydrogen / 5%-palladium/activated carbon / methanol / 3 h / 45 °C / 3750.38 Torr / Industry scale

5.1: caesium carbonate / palladium diacetate; 4,5’-bis(diphenylphosphino)-9,9’-dimethylxanthene / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere; Industry scale

6.1: Prochrom 200mm 20jim Chiralpak AD column / n-heptane; ethanol; methanol / Resolution of racemate

With water; hydrogen; potassium acetate; caesium carbonate; trifluoroacetic acid; potassium hydroxide; 4,5’-bis(diphenylphosphino)-9,9’-dimethylxanthene; 5%-palladium/activated carbon; palladium diacetate; triphenylphosphine; In 1,4-dioxane; methanol; ethanol; n-heptane; dichloromethane; N,N-dimethyl-formamide;