8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-6-(morpholine-4-carbonyl)-2-morpholino-4H-chromen-4-one

Base Information

Chemical Name:8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-6-(morpholine-4-carbonyl)-2-morpholino-4H-chromen-4-one
CAS No.:1403458-26-3
Molecular Formula:C₂₈H₂₉F₂N₃O₅
Molecular Weight:525.552
Hs Code.:

Synonyms:8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-6-(morpholine-4-carbonyl)-2-morpholino-4H-chromen-4-one

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Chemical Property of 8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-6-(morpholine-4-carbonyl)-2-morpholino-4H-chromen-4-one

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Technology Process of 8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-6-(morpholine-4-carbonyl)-2-morpholino-4H-chromen-4-one

There total 19 articles about 8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-6-(morpholine-4-carbonyl)-2-morpholino-4H-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 461-96-1
3,5-difluorobromobenzene

: 1403458-70-7
6-(morpholine-4-carbonyl)-2-morpholino-8-(pyrrolidin-2-yl)-4H-chromen-4-one

: 1403458-26-3
8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-6-(morpholine-4-carbonyl)-2-morpholino-4H-chromen-4-one

Guidance literature:: With caesium carbonate; 4,5’-bis(diphenylphosphino)-9,9’-dimethylxanthene; palladium diacetate; In 1,4-dioxane; at 100 ℃; for 2h; Inert atmosphere; Industry scale;

Reference yield: 59.3%

: 110-91-8,99108-56-2
morpholine

: 1403458-62-7
8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-2-morpholino-4-oxo-4H-chromene-6-carboxylic acid

: 1403458-26-3
8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-6-(morpholine-4-carbonyl)-2-morpholino-4H-chromen-4-one

Guidance literature:: With 2-hydroxy-pyridine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 20 ℃; for 4h; Inert atmosphere;

Reference yield:

: 99-76-3,156291-94-0
methyl 4-hydroxylbenzoate

: 1403458-26-3
8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-6-(morpholine-4-carbonyl)-2-morpholino-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 10 steps

1.1: bromine / dichloromethane / 36 h / 0 - 20 °C / Inert atmosphere

2.1: triethylamine / palladium diacetate; 1,1'-bis(diphenylphosphino)ferrocene / ethanol / 70 °C / Inert atmosphere

3.1: bromine; pyridine / dichloromethane / 2 h / 0 - 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -65 - 0 °C / Inert atmosphere

4.2: 2 h / 20 °C

5.1: trifluoromethylsulfonic anhydride / 1,2-dichloro-ethane / 50 °C / Inert atmosphere

6.1: potassium hydroxide; water / 5 h / 20 °C / Industry scale

6.2: 7 °C

7.1: triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere; Industry scale

8.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C / Industry scale

9.1: hydrogen / 5%-palladium/activated carbon / methanol / 3 h / 45 °C / 3750.38 Torr / Industry scale

10.1: caesium carbonate / palladium diacetate; 4,5’-bis(diphenylphosphino)-9,9’-dimethylxanthene / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere; Industry scale

With pyridine; trifluoromethylsulfonic anhydride; water; hydrogen; bromine; caesium carbonate; triethylamine; trifluoroacetic acid; potassium hydroxide; lithium hexamethyldisilazane; 1,1'-bis(diphenylphosphino)ferrocene; 4,5’-bis(diphenylphosphino)-9,9’-dimethylxanthene; 5%-palladium/activated carbon; palladium diacetate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;