1-(2-(pyridin-4-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-5(4H)-yl)-2-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-2-yl)ethan-1-one

Base Information

Chemical Name:1-(2-(pyridin-4-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-5(4H)-yl)-2-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-2-yl)ethan-1-one
CAS No.:1190970-17-2
Molecular Formula:C₂₅H₂₅F₃N₄O₃S₂
Molecular Weight:550.626
Hs Code.:

Synonyms:1-(2-(pyridin-4-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-5(4H)-yl)-2-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-2-yl)ethan-1-one

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Chemical Property of 1-(2-(pyridin-4-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-5(4H)-yl)-2-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-2-yl)ethan-1-one

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Technology Process of 1-(2-(pyridin-4-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-5(4H)-yl)-2-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-2-yl)ethan-1-one

There total 6 articles about 1-(2-(pyridin-4-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-5(4H)-yl)-2-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-2-yl)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1073696-63-5
2-[1-[[3-(Trifluoromethyl)phenyl]sulfonyl]-piperidin-2-yl]-acetic acid

: C₂HF₃O₂*C₁₁H₁₁N₃S

: 1190970-17-2
1-(2-(pyridin-4-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-5(4H)-yl)-2-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-2-yl)ethan-1-one

Guidance literature:: 2-[1-[[3-(Trifluoromethyl)phenyl]sulfonyl]-piperidin-2-yl]-acetic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 0.25h;

C₂HF₃O₂*C₁₁H₁₁N₃S; In dichloromethane; at 25 ℃; Cooling with ice;

Reference yield:

: 16179-97-8
pyridin-2-yl acetic acid hydrochloride

: 1190970-17-2
1-(2-(pyridin-4-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-5(4H)-yl)-2-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-2-yl)ethan-1-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / platinum(IV) oxide / methanol / 2 h

2.1: thionyl chloride / 0 - 65 °C

3.1: potassium carbonate / dichloromethane / 8.17 h / 20 °C

4.1: methanol; potassium hydroxide / 6 h / 20 °C

4.2: 0 °C / pH 2

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 25 °C

5.2: 25 °C / Cooling with ice

With methanol; thionyl chloride; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; platinum(IV) oxide; In methanol; dichloromethane;

Reference yield:

: C₁₆H₁₉N₃O₂S

: 1190970-17-2
1-(2-(pyridin-4-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-5(4H)-yl)-2-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-2-yl)ethan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 0 - 25 °C

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 25 °C

2.2: 25 °C / Cooling with ice

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;