PIPERIDIN-2-YL-ACETIC ACID HYDROCHLORIDE

Base Information

• Chemical Name: PIPERIDIN-2-YL-ACETIC ACID HYDROCHLORIDE
• CAS No.: 19615-30-6
• Molecular Formula: C₇H₁₃NO₂*ClH
• Molecular Weight: 179.647
• Hs Code.: 2933399090
• Mol file: 19615-30-6.mol

Synonyms:2-Piperidineaceticacid, hydrochloride (8CI,9CI)

Chemical Property of PIPERIDIN-2-YL-ACETIC ACID HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 7.77E-05mmHg at 25°C
• Melting Point: 183-186 °C(lit.)
• Boiling Point: 318.1°C at 760 mmHg
• Flash Point: 146.2°C
• PSA: 49.33000
• LogP: 1.73400

Purity/Quality:

98%min ^*data from raw suppliers

2-PiperidylaceticAcidHydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C,Xn
• Statements: 20/21/22-34-41-22
• Safety Statements: 26-36/37/39-45-39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Reactant for:? ;Enantiopure piperidine based β-amino esters via chemoenzymatic approach1? ;Esterification2

Technology Process of PIPERIDIN-2-YL-ACETIC ACID HYDROCHLORIDE

There total 4 articles about PIPERIDIN-2-YL-ACETIC ACID HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

pyridin-2-yl acetic acid hydrochloride (16179-97-8) → piperidin-2-yl-acetic acid hydrochloride (19615-30-6)

Guidance literature:

With hydrogen; platinum(IV) oxide; In methanol; for 2h;

Reference yield:

2-pyridineacetic acid (13115-43-0) → piperidin-2-yl-acetic acid hydrochloride (19615-30-6)

Guidance literature:

With hydrogenchloride; hydrogen; platinum(IV) oxide; at 20 ℃; for 50h; under 3750.3 Torr;

DOI:10.1016/j.tetasy.2007.01.027

Reference yield:

1-formyl-2-methoxy-piperidine (61020-07-3) → piperidin-2-yl-acetic acid hydrochloride (19615-30-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / AlCl₃ / CH₂Cl₂ / 20 h / Ambient temperature

2: 1.) aq. NaOH, 2.) aq. HCl / 1) reflux, 20 h; 3) 100 deg C, 1 mmHg

With hydrogenchloride; sodium hydroxide; aluminium trichloride; In dichloromethane;

upstream raw materials:

dimethyl (1-formyl-2-piperidyl)-malonate

2-pyridineacetic acid

1-formyl-2-methoxy-piperidine

pyridin-2-yl acetic acid hydrochloride

Downstream raw materials:

1-(2-(pyridin-4-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-5(4H)-yl)-2-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-2-yl)ethan-1-one

2-[1-[[3-(Trifluoromethyl)phenyl]sulfonyl]-piperidin-2-yl]-acetic acid

[1-(3-trifluoromethyl-benzenesulfonyl)-piperidin-2-yl]-acetic acid methyl ester

piperidin-2-yl-acetic acid methyl ester

Refernces

• 1、 Liljeblad, Arto,Kavenius, Hanna-Maija,Taehtinen, Petri,Kanerva, Liisa T.. "Chemoenzymatic approach to enantiopure piperidine-based β-amino esters in organic solvents". . p. 181 - 191. Retrieved 2007/10/03.