4'-demethyl-4β-(3,5-difluoroanilino)-4-desoxypodophyllotoxin

Base Information

• Chemical Name: 4'-demethyl-4β-(3,5-difluoroanilino)-4-desoxypodophyllotoxin
• CAS No.: 125830-37-7
• Molecular Formula: C₂₇H₂₃F₂NO₇
• Molecular Weight: 511.479
• Mol file: 125830-37-7.mol

Synonyms:4'-demethyl-4β-(3,5-difluoroanilino)-4-desoxypodophyllotoxin

Chemical Property of 4'-demethyl-4β-(3,5-difluoroanilino)-4-desoxypodophyllotoxin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4'-demethyl-4β-(3,5-difluoroanilino)-4-desoxypodophyllotoxin

There total 4 articles about 4'-demethyl-4β-(3,5-difluoroanilino)-4-desoxypodophyllotoxin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

4'-O-demethyl-4β-bromo-4-desoxypodophyllotoxin (16477-16-0) + 3,5-difluoroaniline (372-39-4) → 4'-demethyl-4β-(3,5-difluoroanilino)-4-desoxypodophyllotoxin (125830-37-7) + 4'-demethyl-4α-(3,5-difluoroanilino)-4-desoxypodophyllotoxin (125830-37-7)

Guidance literature:

With barium carbonate; In dichloromethane; Ambient temperature;

DOI:10.1021/jm00167a013

Reference yield: 50.0%

4'-O-demethyl-4β-bromo-4-desoxypodophyllotoxin (16477-16-0) + 3,5-difluoroaniline (372-39-4) → 4'-demethyl-4β-(3,5-difluoroanilino)-4-desoxypodophyllotoxin (125830-37-7) + 4'-demethyl-4α-(3,5-difluoroanilino)-4-desoxypodophyllotoxin (125830-37-7)

Guidance literature:

With barium carbonate; In dichloromethane; Ambient temperature;

DOI:10.1021/jm00167a013

Reference yield:

4'-demethylepipodophyllotoxin (6559-91-7) → 4'-demethyl-4β-(3,5-difluoroanilino)-4-desoxypodophyllotoxin (125830-37-7)

Guidance literature:

Multi-step reaction with 2 steps

1: HBr / CH₂Cl₂ / 0.75 h / 0 °C

2: 50 percent / barium carbonate / CH₂Cl₂ / Ambient temperature

With hydrogen bromide; barium carbonate; In dichloromethane;

DOI:10.1021/jm00167a013

upstream raw materials:

4'-O-demethyl-4β-bromo-4-desoxypodophyllotoxin

3,5-difluoroaniline

4'-demethylepipodophyllotoxin