ethyl (2,4,5-trioxo-3-phenethyl-imidazolidin-1-yl)ethanoate

Base Information

• Chemical Name: ethyl (2,4,5-trioxo-3-phenethyl-imidazolidin-1-yl)ethanoate
• CAS No.: 128043-74-3
• Molecular Formula: C₁₅H₁₆N₂O₅
• Molecular Weight: 304.302
• Mol file: 128043-74-3.mol

Synonyms:ethyl (2,4,5-trioxo-3-phenethyl-imidazolidin-1-yl)ethanoate

Chemical Property of ethyl (2,4,5-trioxo-3-phenethyl-imidazolidin-1-yl)ethanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (2,4,5-trioxo-3-phenethyl-imidazolidin-1-yl)ethanoate

There total 5 articles about ethyl (2,4,5-trioxo-3-phenethyl-imidazolidin-1-yl)ethanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-(2-phenethyl)imidazolidine-2,4,5-trione (92764-04-0) + ethyl bromoacetate (105-36-2) → ethyl (2,4,5-trioxo-3-phenethyl-imidazolidin-1-yl)ethanoate (128043-74-3)

Guidance literature:

With potassium hydroxide; In ethanol; for 9h; Reflux;

DOI:10.1016/j.ejmech.2011.01.035

Reference yield:

(2-phenylethyl)urea (2158-04-5) → ethyl (2,4,5-trioxo-3-phenethyl-imidazolidin-1-yl)ethanoate (128043-74-3)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 3 h / Ambient temperature

2: KOH / ethanol / 8 h / Heating

With potassium hydroxide; In tetrahydrofuran; ethanol;

DOI:10.1021/jm9508393

Reference yield:

2-phenylethylamine hydrochloride (156-28-5) → ethyl (2,4,5-trioxo-3-phenethyl-imidazolidin-1-yl)ethanoate (128043-74-3)

Guidance literature:

Multi-step reaction with 3 steps

1: conc. HCl / H₂O / 3 h / Heating

2: tetrahydrofuran / 3 h / Ambient temperature

3: KOH / ethanol / 8 h / Heating

With hydrogenchloride; potassium hydroxide; In tetrahydrofuran; ethanol; water;

DOI:10.1021/jm9508393

upstream raw materials:

1-(2-phenethyl)imidazolidine-2,4,5-trione

ethyl bromoacetate

(2-phenylethyl)urea

2-phenylethylamine hydrochloride