ethyl N-<4-(N-acetyl-2-cyclohexylethylaminomethyl)-2-(2-methylphenyl)benzoyl>-L-methionine

Base Information

Chemical Name:ethyl N-<4-(N-acetyl-2-cyclohexylethylaminomethyl)-2-(2-methylphenyl)benzoyl>-L-methionine
CAS No.:253449-37-5
Molecular Formula:C₃₂H₄₄N₂O₄S
Molecular Weight:552.778
Hs Code.:

Synonyms:ethyl N-<4-(N-acetyl-2-cyclohexylethylaminomethyl)-2-(2-methylphenyl)benzoyl>-L-methionine

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Chemical Property of ethyl N-<4-(N-acetyl-2-cyclohexylethylaminomethyl)-2-(2-methylphenyl)benzoyl>-L-methionine

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Technology Process of ethyl N-<4-(N-acetyl-2-cyclohexylethylaminomethyl)-2-(2-methylphenyl)benzoyl>-L-methionine

There total 5 articles about ethyl N-<4-(N-acetyl-2-cyclohexylethylaminomethyl)-2-(2-methylphenyl)benzoyl>-L-methionine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 75-36-5
acetyl chloride

: 253449-31-9
ethyl N-<4-(2-cyclohexylethylaminomethyl)-2-(2-methylphenyl)benzoyl>-L-methionine

: 253449-37-5
ethyl N-<4-(N-acetyl-2-cyclohexylethylaminomethyl)-2-(2-methylphenyl)benzoyl>-L-methionine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1021/jm990335v

Reference yield:

: 215919-30-5
methyl 5-(hydroxymethyl)-2'-methyl(1,1'-biphenyl)-2-carboxylate

: 253449-37-5
ethyl N-<4-(N-acetyl-2-cyclohexylethylaminomethyl)-2-(2-methylphenyl)benzoyl>-L-methionine

Guidance literature:: Multi-step reaction with 5 steps

1: aq.LiOH / methanol / 3.5 h / Heating

2: EDCI; HOBt; NMM

4: NaBH(OAc)3 / 1,2-dichloro-ethane / 3 h / 20 °C

5: 100 percent / diisopropylethylamine / tetrahydrofuran / 1 h / 20 °C

With 4-methyl-morpholine; lithium hydroxide; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; 1,2-dichloro-ethane; 1: saponification / 2: Condensation / 3: Swern oxidation / 4: reductive amination / 5: Acetylation;
DOI:10.1021/jm990335v

Reference yield:

: 253449-47-7
5-(hydroxymethyl)-2'-methyl(1,1'-biphenyl)-2-carboxylic Acid

: 253449-37-5
ethyl N-<4-(N-acetyl-2-cyclohexylethylaminomethyl)-2-(2-methylphenyl)benzoyl>-L-methionine

Guidance literature:: Multi-step reaction with 4 steps

1: EDCI; HOBt; NMM

3: NaBH(OAc)3 / 1,2-dichloro-ethane / 3 h / 20 °C

4: 100 percent / diisopropylethylamine / tetrahydrofuran / 1 h / 20 °C

With 4-methyl-morpholine; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,2-dichloro-ethane; 1: Condensation / 2: Swern oxidation / 3: reductive amination / 4: Acetylation;
DOI:10.1021/jm990335v