4-(2,2,2-trifluoro-1-triethylsilanyloxy-1-trifluoromethyl-ethyl)-phenylamine

Base Information

Chemical Name:4-(2,2,2-trifluoro-1-triethylsilanyloxy-1-trifluoromethyl-ethyl)-phenylamine
CAS No.:892121-52-7
Molecular Formula:C₁₅H₂₁F₆NOSi
Molecular Weight:373.414
Hs Code.:

Synonyms:4-(2,2,2-trifluoro-1-triethylsilanyloxy-1-trifluoromethyl-ethyl)-phenylamine

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Chemical Property of 4-(2,2,2-trifluoro-1-triethylsilanyloxy-1-trifluoromethyl-ethyl)-phenylamine

Chemical Property:

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Technology Process of 4-(2,2,2-trifluoro-1-triethylsilanyloxy-1-trifluoromethyl-ethyl)-phenylamine

There total 1 articles about 4-(2,2,2-trifluoro-1-triethylsilanyloxy-1-trifluoromethyl-ethyl)-phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 722-92-9
2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

: 994-30-9
triethylsilyl chloride

: 892121-52-7
4-(2,2,2-trifluoro-1-triethylsilanyloxy-1-trifluoromethyl-ethyl)-phenylamine

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 892121-52-7
4-(2,2,2-trifluoro-1-triethylsilanyloxy-1-trifluoromethyl-ethyl)-phenylamine

: 2-{ethyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-amino}-N-methyl-2-phenyl-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: Py

2: BH₃*THF

3: NaOAc / 2-methyl-propan-2-ol

4: LiOH / tetrahydrofuran; H₂O

5: 73 percent / EDCI; HOBt; NMO

With pyridine; lithium hydroxide; N-methyl-2-indolinone; borane-THF; sodium acetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; water; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2006.06.081

Reference yield:

: 892121-52-7
4-(2,2,2-trifluoro-1-triethylsilanyloxy-1-trifluoromethyl-ethyl)-phenylamine

: 2-phenyl-1-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-piperidine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NaOAc / 2-methyl-propan-2-ol

2: LiHMDA

3: TBAF

With tetrabutyl ammonium fluoride; sodium acetate; In tert-butyl alcohol;
DOI:10.1016/j.bmcl.2006.06.081