5-<1-(S)-(1-Carbethoxy)ethyl>-1,3-dibenzylhexahydro-2-oxo-1,3,5-triazine

Base Information

• Chemical Name: 5-<1-(S)-(1-Carbethoxy)ethyl>-1,3-dibenzylhexahydro-2-oxo-1,3,5-triazine
• CAS No.: 130750-08-2
• Molecular Formula: C₂₂H₂₇N₃O₃
• Molecular Weight: 381.475

Synonyms:5-<1-(S)-(1-Carbethoxy)ethyl>-1,3-dibenzylhexahydro-2-oxo-1,3,5-triazine

Chemical Property of 5-<1-(S)-(1-Carbethoxy)ethyl>-1,3-dibenzylhexahydro-2-oxo-1,3,5-triazine

Chemical Property:

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Technology Process of 5-<1-(S)-(1-Carbethoxy)ethyl>-1,3-dibenzylhexahydro-2-oxo-1,3,5-triazine

There total 2 articles about 5-<1-(S)-(1-Carbethoxy)ethyl>-1,3-dibenzylhexahydro-2-oxo-1,3,5-triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1,3-dibenzylurea (1466-67-7) + (S)-alanine ethyl ester hydrochloride (1115-59-9) → 5-<1-(S)-(1-Carbethoxy)ethyl>-1,3-dibenzylhexahydro-2-oxo-1,3,5-triazine (130750-08-2)

Guidance literature:

With 4-methyl-morpholine; In 1,4-dioxane; water; toluene; at 90 - 110 ℃; for 1.5h;

DOI:10.1016/0040-4039(90)80084-Y

Reference yield:

benzylamine (100-46-9) → 5-<1-(S)-(1-Carbethoxy)ethyl>-1,3-dibenzylhexahydro-2-oxo-1,3,5-triazine (130750-08-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / CH₂Cl₂ / 0.5 h / 5 °C

2: 1) i-Pr₂NEt / 1) H₂O, 10 min, 2) EtOAc, reflux, 1 h

With N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1021/jo00049a036

Reference yield: 94.0%

5-<1-(S)-(1-Carbethoxy)ethyl>-1,3-dibenzylhexahydro-2-oxo-1,3,5-triazine (130750-08-2) → 5-(1-hydroxy-2(S)-propyl)-1,3-dibenzylhexahydro-2-oxo-1,3,5-triazine (143565-44-0)

Guidance literature:

With lithium borohydride; In tetrahydrofuran; for 2h; Heating;

DOI:10.1021/jo00049a036

upstream raw materials:

formaldehyd

1,3-dibenzylurea

(S)-alanine ethyl ester hydrochloride

benzylamine

Downstream raw materials:

5-(1-hydroxy-2(S)-propyl)-1,3-dibenzylhexahydro-2-oxo-1,3,5-triazine

2(S)-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)propionaldehyde

5(S)-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)-4(R)-hydroxyhexene

5(S)-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)-4(S)-hydroxyhexene

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