(2R)-1-(3',5'-dimethoxyphenyl)-N-(tert-butoxycarbonyl)-2-aminopropane

Base Information

• Chemical Name: (2R)-1-(3',5'-dimethoxyphenyl)-N-(tert-butoxycarbonyl)-2-aminopropane
• CAS No.: 1206475-96-8
• Molecular Formula: C₁₆H₂₅NO₄
• Molecular Weight: 295.379
• Mol file: 1206475-96-8.mol

Synonyms:(2R)-1-(3',5'-dimethoxyphenyl)-N-(tert-butoxycarbonyl)-2-aminopropane

Chemical Property of (2R)-1-(3',5'-dimethoxyphenyl)-N-(tert-butoxycarbonyl)-2-aminopropane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-1-(3',5'-dimethoxyphenyl)-N-(tert-butoxycarbonyl)-2-aminopropane

There total 1 articles about (2R)-1-(3',5'-dimethoxyphenyl)-N-(tert-butoxycarbonyl)-2-aminopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-bromo-3,5-dimethoxybenzene (20469-65-2) + (R)-(-)-N-(tert-Butoxycarbonyl)-2-methylaziridine (129319-91-1) → (2R)-1-(3',5'-dimethoxyphenyl)-N-(tert-butoxycarbonyl)-2-aminopropane (1206475-96-8)

Guidance literature:

1-bromo-3,5-dimethoxybenzene; With iodine; magnesium; ethylene dibromide; In tetrahydrofuran; at 20 ℃; Inert atmosphere; Reflux;

(R)-(-)-N-(tert-Butoxycarbonyl)-2-methylaziridine; With copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ja9097687

Reference yield:

(2R)-1-(3',5'-dimethoxyphenyl)-N-(tert-butoxycarbonyl)-2-aminopropane (1206475-96-8) → (1R)-2-(3,5-dimethoxyphenyl)-1-methylethylamine (177971-34-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/ja9097687

upstream raw materials:

1-bromo-3,5-dimethoxybenzene

(R)-(-)-N-(tert-Butoxycarbonyl)-2-methylaziridine

Downstream raw materials:

(1R)-2-(3,5-dimethoxyphenyl)-1-methylethylamine