N-4-(2-propynyloxy)butyl-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-hydroxyethyl oxalamide

Base Information

• Chemical Name: N-4-(2-propynyloxy)butyl-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-hydroxyethyl oxalamide
• CAS No.: 1431462-04-2
• Molecular Formula: C₃₄H₄₀N₂O₇
• Molecular Weight: 588.701
• Mol file: 1431462-04-2.mol

Synonyms:N-4-(2-propynyloxy)butyl-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-hydroxyethyl oxalamide

Chemical Property of N-4-(2-propynyloxy)butyl-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-hydroxyethyl oxalamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-4-(2-propynyloxy)butyl-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-hydroxyethyl oxalamide

There total 4 articles about N-4-(2-propynyloxy)butyl-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-hydroxyethyl oxalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

4-(2-(4,4' dimethoxytrityloxy)ethyl)morpholine 2,3 dione (1397704-93-6) + 4-(prop-2-yn-1-yloxy)butylamine (1431462-03-1) → N-4-(2-propynyloxy)butyl-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-hydroxyethyl oxalamide (1431462-04-2)

Guidance literature:

With pyridine; dmap; at 20 ℃; for 16h;

DOI:10.1021/ol500668n

Reference yield:

N-(2-hydroxyethyl)morpholine-2,3-dione (68898-62-4) → N-4-(2-propynyloxy)butyl-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-hydroxyethyl oxalamide (1431462-04-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 3 h / 20 °C

2: dmap; pyridine / 16 h / 20 °C

With pyridine; dmap;

DOI:10.1021/ol500668n

Reference yield:

4-(prop-2-yn-1-yloxy)butan-1-ol (66865-32-5) → N-4-(2-propynyloxy)butyl-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-hydroxyethyl oxalamide (1431462-04-2)

Guidance literature:

Multi-step reaction with 4 steps

1: thionyl chloride / 24 h / 20 °C / Reflux

2: caesium carbonate / N,N-dimethyl-formamide / 144 h / 20 °C

3: sodium hydroxide; water / 2 h / 20 °C

4: pyridine; dmap / 20 °C

With pyridine; dmap; thionyl chloride; water; caesium carbonate; sodium hydroxide; In N,N-dimethyl-formamide;

DOI:10.1080/15257770.2013.787147

upstream raw materials:

4-(2-(4,4' dimethoxytrityloxy)ethyl)morpholine 2,3 dione

4-(prop-2-yn-1-yloxy)butylamine

N-(2-hydroxyethyl)morpholine-2,3-dione

4-(prop-2-yn-1-yloxy)butan-1-ol

Downstream raw materials:

N-4-(2-propynyloxy)butyl-N'-2-(4,4'-dimethoxytrityloxy)ethyl-N'-2-[(2-cyanoethoxy-N,N-diisopropylaminophosphinyloxy)ethyl]oxalamide