methyl 2-diazo-3-(o-tolyl)propanoate

Base Information

• Chemical Name: methyl 2-diazo-3-(o-tolyl)propanoate
• CAS No.: 1310218-03-1
• Molecular Formula: C₁₁H₁₂N₂O₂
• Molecular Weight: 204.228
• Mol file: 1310218-03-1.mol

Synonyms:methyl 2-diazo-3-(o-tolyl)propanoate

Chemical Property of methyl 2-diazo-3-(o-tolyl)propanoate

Chemical Property:

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Technology Process of methyl 2-diazo-3-(o-tolyl)propanoate

There total 1 articles about methyl 2-diazo-3-(o-tolyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-methylbenzyl)-3-oxo-butyric acid methyl ester (1203476-26-9) → methyl 2-diazo-3-(o-tolyl)propanoate (1310218-03-1)

Guidance literature:

With 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 0 - 20 ℃; for 12h;

DOI:10.1021/ja202070j

Reference yield: 91.0%

methyl 2-diazo-3-(o-tolyl)propanoate (1310218-03-1) + benzoic acid (65-85-0,8013-63-6) → (S)-1-methoxy-1-oxo-3-(o-tolyl)propan-2-yl benzoate + (S)-3-methoxy-3-oxo-2-o-tolylpropyl benzoate

Guidance literature:

With C₂HF₆NO₄S₂*C₂₇H₃₀BNO; In dichloromethane; at -78 ℃; for 2h; enantioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201612655

Reference yield: 46.0%

1,2-diphenylprop-2-en-1-one (4452-11-3) + methyl 2-diazo-3-(o-tolyl)propanoate (1310218-03-1) → C26H24O3 + C26H24O3 + C26H24O3

Guidance literature:

With C₃₈H₅₈N₄O₄; scandium tris(trifluoromethanesulfonate); In dichloromethane; at 0 ℃; for 72h; enantioselective reaction;

DOI:10.1039/c8cc05420g

upstream raw materials:

2-(2-methylbenzyl)-3-oxo-butyric acid methyl ester