4452-11-3Relevant articles and documents
β-Iodo Ketones by Prevost Reaction of Vinyl Carbinols
Ciganek, Engelbert,Calabrese, J. C.
, p. 4439 - 4443 (1995)
Treatment of α-ethenyl-α-phenylbenzenemethanol with iodine and silver acetate in either acetic acid or benzene gave 1,2-diphenyl-3-iodo-1-propanone (6) in 85percent yield.Ring enlargements involving similar rearrangements were observed with a number of cy
Specific alkylidene coupling of the labile diruthenium bridging methylene complex [(η-C5H5)2Ru2(μ-CH 2)(CO)2(MeCN)] with diazoalkanes (N2=CR2) giving alkenic products
Akita, Munetaka,Hua, Ruimao,Knox, Selby A. R.,Moro-oka, Yoshihiko,Nakanishi, Sadahiro,Yates, Michael I.
, p. 51 - 52 (1997)
Reaction of the labile diruthenium bridging methylene complex [(η-C5H5)2Ru2(μ-CH 2)(μ-CO)(CO)(MeCN)] with diazoalkanes (N2=CR1R2) results in specific C-C coupling to g
Asymmetric Catalytic Epoxidation of Terminal Enones for the Synthesis of Triazole Antifungal Agents
Feng, Xiaoming,He, Qianwen,Liu, Xiaohua,Zhang, Dong,Zhang, Fengcai
supporting information, p. 6961 - 6966 (2021/09/11)
An enantioselective epoxidation of α-substituted vinyl ketones was realized to construct the key epoxide intermediates for the synthesis of various triazole antifungal agents. The reaction proceeded efficiently in high yields with good enantioselectivities by employing a chiral N,N′-dioxide/ScIII complex as the chiral catalyst and 35% aq. H2O2 as the oxidant. It enabled the facile transformation for optically active isavuconazole, efinaconazole, and other potential antifungal agents.
Cu/Pd-catalyzed borocarbonylative trifunctionalization of alkynes and allenes: synthesis of β-geminal-diboryl ketones
Yuan, Yang,Wu, Fu-Peng,Spannenberg, Anke,Wu, Xiao-Feng
, p. 2142 - 2153 (2021/09/06)
Functionalized bisboryl compounds have recently emerged as a new class of synthetically useful building blocks in organic synthesis. Herein, we report an efficient strategy to synthesize β-geminal-diboryl ketones enabled by a Cu/Pd-catalyzed borocarbonylative trifunctionalization of readily available alkynes and allenes. This reaction promises to be a useful method for the synthesis of functionalized β-geminal-diboryl ketones with broad functional group tolerance. Mechanistic studies suggest that the reaction proceeds through borocarbonylation/hydroboration cascade of both alkynes and allenes. [Figure not available: see fulltext.]