N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]amino-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N,N-trimethylammonium iodide

Base Information

Chemical Name:N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]amino-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N,N-trimethylammonium iodide
CAS No.:1017278-90-8
Molecular Formula:C₃₆H₄₅ClN₃O₅*I
Molecular Weight:762.128
Hs Code.:

N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]amino-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N,N-trimethylammonium iodide

Synonyms:N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]amino-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N,N-trimethylammonium iodide

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Chemical Property of N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]amino-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N,N-trimethylammonium iodide

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Technology Process of N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]amino-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N,N-trimethylammonium iodide

There total 8 articles about N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]amino-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N,N-trimethylammonium iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1017278-82-8
5-[bis(tert-butoxycarbonyl)]amino-1-(chloromethyl)-3-[(E)-4-(dimethylaminomethyl)cinnamoyl]-1,2-dihydro-3H-benzo[e]indole

: 74-88-4
methyl iodide

: 1017278-90-8
N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]amino-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N,N-trimethylammonium iodide

Guidance literature:: In ethyl acetate; at 20 ℃; for 16h; Darkness;
DOI:10.1016/j.bmc.2011.12.007

Reference yield:

: 1017278-95-3
(E)-4-(dimethylaminomethyl)cinnamic acid hydrochloride

: 1017278-90-8
N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]amino-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N,N-trimethylammonium iodide

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide; acetonitrile / 5.5 h / 20 °C

2.1: triethylamine / tetrahydrofuran / 0.75 h / 20 °C

2.2: 12 h / 20 °C

3.1: ethyl acetate / 16 h / 20 °C / Darkness

With oxalyl dichloride; triethylamine; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2011.12.007

Reference yield:

: 1017279-66-1
methyl (E)-4-(dimethylaminomethyl)cinnamate

: 1017278-90-8
N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]amino-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N,N-trimethylammonium iodide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / methanol; water / 2 h / Reflux

1.2: 20 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide; acetonitrile / 5.5 h / 20 °C

3.1: triethylamine / tetrahydrofuran / 0.75 h / 20 °C

3.2: 12 h / 20 °C

4.1: ethyl acetate / 16 h / 20 °C / Darkness

With oxalyl dichloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2011.12.007