Methanesulfonic acid (3S,6R,7S)-3-(4-benzyloxy-benzyl)-7-chloro-4-[(S)-5-(2-oxo-4,5-diphenyl-oxazol-3-yl)-2-(2-trimethylsilanyl-ethanesulfonylamino)-pentanoyl]-[1,4]oxazocan-6-yl ester

Base Information

Chemical Name:Methanesulfonic acid (3S,6R,7S)-3-(4-benzyloxy-benzyl)-7-chloro-4-[(S)-5-(2-oxo-4,5-diphenyl-oxazol-3-yl)-2-(2-trimethylsilanyl-ethanesulfonylamino)-pentanoyl]-[1,4]oxazocan-6-yl ester
CAS No.:183794-39-0
Molecular Formula:C₄₆H₅₆ClN₃O₁₀S₂Si
Molecular Weight:938.635
Hs Code.:

Methanesulfonic acid (3S,6R,7S)-3-(4-benzyloxy-benzyl)-7-chloro-4-[(S)-5-(2-oxo-4,5-diphenyl-oxazol-3-yl)-2-(2-trimethylsilanyl-ethanesulfonylamino)-pentanoyl]-[1,4]oxazocan-6-yl ester

Synonyms:Methanesulfonic acid (3S,6R,7S)-3-(4-benzyloxy-benzyl)-7-chloro-4-[(S)-5-(2-oxo-4,5-diphenyl-oxazol-3-yl)-2-(2-trimethylsilanyl-ethanesulfonylamino)-pentanoyl]-[1,4]oxazocan-6-yl ester

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Chemical Property of Methanesulfonic acid (3S,6R,7S)-3-(4-benzyloxy-benzyl)-7-chloro-4-[(S)-5-(2-oxo-4,5-diphenyl-oxazol-3-yl)-2-(2-trimethylsilanyl-ethanesulfonylamino)-pentanoyl]-[1,4]oxazocan-6-yl ester

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Technology Process of Methanesulfonic acid (3S,6R,7S)-3-(4-benzyloxy-benzyl)-7-chloro-4-[(S)-5-(2-oxo-4,5-diphenyl-oxazol-3-yl)-2-(2-trimethylsilanyl-ethanesulfonylamino)-pentanoyl]-[1,4]oxazocan-6-yl ester

There total 16 articles about Methanesulfonic acid (3S,6R,7S)-3-(4-benzyloxy-benzyl)-7-chloro-4-[(S)-5-(2-oxo-4,5-diphenyl-oxazol-3-yl)-2-(2-trimethylsilanyl-ethanesulfonylamino)-pentanoyl]-[1,4]oxazocan-6-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 124-63-0
methanesulfonyl chloride

: 183794-38-9
2-Trimethylsilanyl-ethanesulfonic acid [(S)-1-[(3S,6R,7S)-3-(4-benzyloxy-benzyl)-7-chloro-6-hydroxy-[1,4]oxazocane-4-carbonyl]-4-(2-oxo-4,5-diphenyl-oxazol-3-yl)-butyl]-amide

: 183794-39-0
Methanesulfonic acid (3S,6R,7S)-3-(4-benzyloxy-benzyl)-7-chloro-4-[(S)-5-(2-oxo-4,5-diphenyl-oxazol-3-yl)-2-(2-trimethylsilanyl-ethanesulfonylamino)-pentanoyl]-[1,4]oxazocan-6-yl ester

Guidance literature:: With triethylamine; In dichloromethane; for 1.5h; Ambient temperature;
DOI:10.1021/jo961114p

Reference yield:

: 21240-34-6
4,5-diphenyl-1,3-dioxol-2-one

: 183794-39-0
Methanesulfonic acid (3S,6R,7S)-3-(4-benzyloxy-benzyl)-7-chloro-4-[(S)-5-(2-oxo-4,5-diphenyl-oxazol-3-yl)-2-(2-trimethylsilanyl-ethanesulfonylamino)-pentanoyl]-[1,4]oxazocan-6-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) Me₄NOH / 1.) MeOH, EtOH, 2.) DMF, 3 h

2: 93 percent / SOCl₂ / 23 h / Ambient temperature

3: 84 percent / triethylamine / dimethylformamide / 2.5 h / 0 °C

4: 97 percent / aq. LiOH / tetrahydrofuran / 2.5 h / Ambient temperature

5: 66 percent / PCl₅ / tetrahydrofuran / 1.75 h / 0 °C

6: 82 percent / Bu₄NF / tetrahydrofuran / 0.5 h

7: 94 percent / triethylamine / CH₂Cl₂ / 1.5 h / Ambient temperature

With lithium hydroxide; thionyl chloride; phosphorus pentachloride; tetramethyl ammoniumhydroxide; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo961114p

Reference yield:

: 21887-64-9
N₂-(tert-butoxycarbonyl)-L-ornithine

: 183794-39-0
Methanesulfonic acid (3S,6R,7S)-3-(4-benzyloxy-benzyl)-7-chloro-4-[(S)-5-(2-oxo-4,5-diphenyl-oxazol-3-yl)-2-(2-trimethylsilanyl-ethanesulfonylamino)-pentanoyl]-[1,4]oxazocan-6-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) Me₄NOH / 1.) MeOH, EtOH, 2.) DMF, 3 h

2: 93 percent / SOCl₂ / 23 h / Ambient temperature

3: 84 percent / triethylamine / dimethylformamide / 2.5 h / 0 °C

4: 97 percent / aq. LiOH / tetrahydrofuran / 2.5 h / Ambient temperature

5: 66 percent / PCl₅ / tetrahydrofuran / 1.75 h / 0 °C

6: 82 percent / Bu₄NF / tetrahydrofuran / 0.5 h

7: 94 percent / triethylamine / CH₂Cl₂ / 1.5 h / Ambient temperature

With lithium hydroxide; thionyl chloride; phosphorus pentachloride; tetramethyl ammoniumhydroxide; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo961114p