N-(3-Amino-3-methylbutyl)-6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]-pyridine-3-carboxamide

Base Information

Chemical Name:N-(3-Amino-3-methylbutyl)-6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]-pyridine-3-carboxamide
CAS No.:1609341-14-1
Molecular Formula:C₂₁H₂₃ClF₂N₄O₂
Molecular Weight:436.889
Hs Code.:

Synonyms:N-(3-Amino-3-methylbutyl)-6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]-pyridine-3-carboxamide

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Chemical Property of N-(3-Amino-3-methylbutyl)-6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]-pyridine-3-carboxamide

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Technology Process of N-(3-Amino-3-methylbutyl)-6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]-pyridine-3-carboxamide

There total 7 articles about N-(3-Amino-3-methylbutyl)-6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]-pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: tert-butyl {4-[({6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}-carbonyl)amino]-2-methylbutan-2-yl}carbamate trifluoroacetate

: 1609341-14-1
N-(3-Amino-3-methylbutyl)-6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]-pyridine-3-carboxamide

Guidance literature:: With hydrogenchloride; In diethyl ether; at 20 ℃;

Reference yield:

: 74115-12-1
5-chloropyridin-3-ol

: 1609341-14-1
N-(3-Amino-3-methylbutyl)-6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]-pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid; nitric acid / 0 - 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: hydrogenchloride; iron / ethanol; water / 0.5 h / Reflux

4.1: ethanol / Molecular sieve; Reflux

5.1: water; lithium hydroxide / methanol; tetrahydrofuran / 20 °C

6.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.17 h / 20 °C

6.2: 20 °C

7.1: hydrogenchloride / diethyl ether / 20 °C

With 4-methyl-morpholine; hydrogenchloride; sulfuric acid; water; nitric acid; iron; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; lithium hydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 936247-35-7
5-chloro-2-nitropyridin-3-ol

: 1609341-14-1
N-(3-Amino-3-methylbutyl)-6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]-pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: hydrogenchloride; iron / ethanol; water / 0.5 h / Reflux

3.1: ethanol / Molecular sieve; Reflux

4.1: water; lithium hydroxide / methanol; tetrahydrofuran / 20 °C

5.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.17 h / 20 °C

5.2: 20 °C

6.1: hydrogenchloride / diethyl ether / 20 °C

With 4-methyl-morpholine; hydrogenchloride; water; iron; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; lithium hydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; water; N,N-dimethyl-formamide;