74115-12-1

Basic information

• Product Name: 5-Chloro-3-pyridinol
• Synonyms: 5-CHLORO-3-PYRIDINOL 99%;3-Pyridinol, 5-chloro-;5-Chloro-3-pyridinol,99%;5-Chloro-3-hydroxypyridine,99%;5-Chloro-3-hydroxypyridine 99%;5-CHLOROPYRIDIN-3-OL;5-CHLORO-3-PYRIDINOL;5-CHLORO-3-HYDROXYPYRIDINE
• CAS NO: 74115-12-1
• Molecular Formula: C₅H₄ClNO
• Molecular Weight: 129.54
• EINECS: 277-727-7
• Product Categories: PYRIDINE;Pyridines, Pyrimidines, Purines and Pteredines;Halides;Pyridines;Chloropyridines;Halopyridines;Heterocycle-Pyridine series
• Mol File: 74115-12-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 160-162 °C(lit.)
• Boiling Point: 324.7 °C at 760 mmHg
• Flash Point: 150.2 °C
• Appearance: orange-brown to brown crystalline powder
• Density: 1.2309 (rough estimate)
• Vapor Pressure: 0.000128mmHg at 25°C
• Refractive Index: 1.4510 (estimate)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 8.37±0.10(Predicted)
• Water Solubility: Soluble in water.
• BRN: 1422550
• CAS DataBase Reference: 5-Chloro-3-pyridinol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-3-pyridinol(74115-12-1)
• EPA Substance Registry System: 5-Chloro-3-pyridinol(74115-12-1)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• Hazardous Substances Data: 74115-12-1(Hazardous Substances Data)

Usage

Chemical Properties

orange-brown to brown crystalline powder

Uses

5-Chloro-3-hydroxypyridine is used in the preparation of 4-(5-chloropyridin-3-yloxy)isoquinoline

General Description

5-Chloro-3-hydroxypyridine undergoes Suzuki-Miyaura cross-coupling with 3-pyridylboronic acid in the presence of Pd catalyst to yield hydroxybiphenyls.

InChI:InChI=1/C5H4ClNO/c6-4-1-5(8)3-7-2-4/h1-3,8H

Upstream product

• 617-89-0 furan-2-ylmethanamine 
• 108-10-1 4-methyl-2-pentanone 
• 2457-47-8 3,5-dichloropyridine 
• 13473-01-3 5-chloro-2-methoxypyridine 

Downstream Products

• 95881-83-7 5-chloro-3-methoxypyridine 
• 235428-02-1 2-(3-chloro-5-pyridyloxy)-5-nitrobenzotrifluoride 
• 1025946-18-2 C₁₇H₈Cl₂F₃NO₃ 
• 1027839-92-4 C₁₃H₁₀ClNO₂ 
• 1007552-00-2 C₁₆H₉ClN₂O₅ 
• 1007552-01-3 C₁₆H₉ClN₂O₅ 
• 1026746-25-7 C₁₆H₁₁ClN₂O₃ 
• 1027245-70-0 C₁₂H₉ClN₂O₄S 
• 1026417-25-3 C₁₄H₁₀ClNO₂ 
• 1027565-38-3 C₁₂H₇ClFNO₂ 
• 1007552-05-7 C₁₂H₇ClN₂O₄ 
• 1026431-65-1 C₁₆H₁₇ClN₂O₂ 
• 1027828-71-2 C₁₃H₁₁ClN₂O₂ 
• 1026532-28-4 C₁₇H₉ClF₃NO₃ 

Relevant articles and documents

THE REACTIONS OF SOME HALOGENATED PYRIDINES WITH METHOXYDE AND METHANETHIOLATE IONS IN DIMETHYLFORMAMIDE

The reactions of 2,6- and 2,5-dibromopyridines and of 2,3- and 3,5-dichloropyridines with sodium isopropanethiolate and methanethiolate afforded the products of mono- or of bis-substitution depending on the experimental conditions.The same pyridines reacted with sodium methoxide to give good yields of the mono-substituted products; bis-substitution occurred easily only in the case of the 2,6-dibromo- and of the 3,5-dichloropyridine.The syntheses of some methoxy thiomethoxypyridine, starting from the halogeno methoxypyridines or from the halogeno thiomethoxypyridines are also described.The bis-(alkylthio)pyridines can be fragmented by sodium in HMPA to give the bis(mercapto)pyridines.