ethyl N-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-β-alaninate

Base Information

Chemical Name:ethyl N-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-β-alaninate
CAS No.:1334607-98-5
Molecular Formula:C₂₈H₃₂F₃N₃O₃
Molecular Weight:515.576
Hs Code.:

Synonyms:ethyl N-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-β-alaninate

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Chemical Property of ethyl N-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-β-alaninate

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Technology Process of ethyl N-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-β-alaninate

There total 7 articles about ethyl N-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-β-alaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 924-73-2
3-amino-propionic acid ethyl ester

: 1334607-97-4
2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}benzaldehyde

: 1334607-98-5
ethyl N-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-β-alaninate

Guidance literature:: 3-amino-propionic acid ethyl ester; 2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}benzaldehyde; With sodium acetate; acetic acid; In ethanol; at 20 ℃; for 0.333333h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃;

With sodium hydrogencarbonate; In dichloromethane; for 0.0833333h;

Reference yield:

: 393-37-3
5-bromo-2-fluorobenzotrifluoride

: 1334607-98-5
ethyl N-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-β-alaninate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 50 °C / Inert atmosphere

1.2: 50 °C

2.1: n-butyllithium / tetrahydrofuran / -78 - -60 °C

2.2: -60 - 20 °C

2.3: 20 °C

3.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.25 h / 120 °C / Inert atmosphere; Sealed; Microwave irradiation

4.1: sodium acetate; acetic acid / ethanol / 0.33 h / 20 °C

4.2: 20 °C

4.3: 0.08 h

With potassium phosphate; n-butyllithium; potassium tert-butylate; sodium acetate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 2357-47-3
4-Fluoro-3-trifluoromethylaniline

: 1334607-98-5
ethyl N-[(2-ethyl-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}phenyl)methyl]-β-alaninate

Guidance literature:: Multi-step reaction with 5 steps

1.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 20 °C / Cooling with ice; Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 50 °C / Inert atmosphere

2.2: 50 °C

3.1: n-butyllithium / tetrahydrofuran / -78 - -60 °C

3.2: -60 - 20 °C

3.3: 20 °C

4.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.25 h / 120 °C / Inert atmosphere; Sealed; Microwave irradiation

5.1: sodium acetate; acetic acid / ethanol / 0.33 h / 20 °C

5.2: 20 °C

5.3: 0.08 h

With potassium phosphate; n-butyllithium; tert.-butylnitrite; potassium tert-butylate; sodium acetate; acetic acid; copper(ll) bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetonitrile;