924-73-2

Basic information

• Product Name: 3-AMINO-PROPIONIC ACID ETHYL ESTER
• Synonyms: BETA-ALANINE ETHYL ESTER;3-AMINO-PROPIONIC ACID ETHYL ESTER;RARECHEM AL BW 0065;b-Alanine, ethyl ester;Ethyl 3-aMinopropanoate;Ethyl 3-aminopropanoate HCl;amino propionic acid ethyl ester
• CAS NO: 924-73-2
• Molecular Formula: C₅H₁₁NO₂
• Molecular Weight: 117.15
• Mol File: 924-73-2.mol
• Article Data: 22

Chemical Properties

• Melting Point: 113-114 °C(Solv: benzene (71-43-2))
• Boiling Point: 54-56 °C
• Appearance: /
• Density: 0.990±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 8.80±0.10(Predicted)
• CAS DataBase Reference: 3-AMINO-PROPIONIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-PROPIONIC ACID ETHYL ESTER(924-73-2)
• EPA Substance Registry System: 3-AMINO-PROPIONIC ACID ETHYL ESTER(924-73-2)

Safety Data

• Hazard Codes: Xi
• Statements: 37/38-41-52
• Safety Statements: 26-39
• Hazardous Substances Data: 924-73-2(Hazardous Substances Data)

Usage

General Description

3-amino-propionic acid ethyl ester, also known as beta-alanine ethyl ester, is a chemical compound that is derived from the amino acid beta-alanine. It is commonly used in the production of pharmaceuticals and as a precursor in the synthesis of various organic compounds. 3-AMINO-PROPIONIC ACID ETHYL ESTER has been researched for its potential use as a supplement in the sports and fitness industry, as it may help to increase athletic performance and improve muscle endurance. Additionally, it has also been studied for its potential neuroprotective and antioxidant properties, making it a promising candidate for the development of new drugs and treatments. Overall, 3-amino-propionic acid ethyl ester is a versatile and valuable chemical compound with a wide range of potential applications in various industries.

Upstream product

• 64-17-5 ethanol 
• 6057-90-5 β-alanine hydrochloride 
• 107-95-9 3-amino propanoic acid 
• 624-85-1 ethyl hypochlorite 
• 23583-21-3 ethyl-3-benzylamino propionate 
• 4244-84-2 ethyl β-alaninate hydrochloride 
• 86544-57-2 3-(Benzyl-hydroxy-amino)-propionic acid ethyl ester 
• 539-74-2 Ethyl 3-bromopropionate 
• 140-88-5 ethyl acrylate 
• 88574-53-2 3-tert-butoxycarbonylamino-propionic acid ethyl ester 
• 2318-25-4 ethyl 3-ethoxy-3-iminopropanoate hydrochloride 
• 7664-41-7 ammonia 
• 40139-55-7 3-azidopropionic acid ethyl ester 
• 31295-20-2 N-acetyl β-Ala-OMe 

Downstream Products

• 161617-96-5 3-Benzyloxycarbonylamino-propionic acid ethyl ester 
• 50463-83-7 ethyl 3-(1-pyrrolo)propanoate 
• 3518-88-5 3,3'-imino-di-propionic acid diethyl ester 
• 289637-65-6 ethyl 3-[(4-chlorobenzyl)-(4-methoxybenzenesulfonyl)-amino]-propionate 
• 881312-74-9 ethyl N-[2-(4-bromophenyl)-6-fluoroquinolin-4-yl]-beta-alaninate 
• 881310-88-9 ethyl N-[2-(4-bromophenyl)quinazolin-4-yl]-beta-alaninate 
• 881311-29-1 ethyl N-[2-(4-bromophenyl)quinolin-4-yl]-beta-alaninate 
• 3783-61-7 diethyl 2-azabutane-1,4-dicarboxylate 
• 23583-21-3 ethyl-3-benzylamino propionate 
• 950493-17-1 ethyl 3-{[(4-nitrophenoxy)carbonyl]amino}propanoate 
• 143467-53-2 2,2'-Dithio-bis 
• 142688-69-5 N-((2-(O-Ethyl)carboxy)ethyl) 2(S)-((3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-cyclohexylmethyl-5(S)-oxazolidinyl)methyl)-3-methylbutanamide 
• 151978-67-5 3-(2-amino-5-iodo)benzamidopropionic acid ethyl ester 
• 93129-43-2 3-(3,4-Dimethoxy-benzenesulfonylamino)-propionic acid ethyl ester 

Relevant articles and documents

Favipiravir-Based Ionic Liquids as Potent Antiviral Drugs for Oral Delivery: Synthesis, Solubility, and Pharmacokinetic Evaluation

Coronavirus disease 2019 (COVID-19) has spread across the world, and no specific antiviral drugs have yet been approved to combat this disease. Favipiravir (FAV) is an antiviral drug that is currently in clinical trials for use against COVID-19. However, the delivery of FAV is challenging because of its limited solubility, and its formulation is difficult with common organic solvents and water. To address these issues, four FAV ionic liquids (FAV-ILs) were synthesized as potent antiviral prodrugs and were fully characterized by nuclear magnetic resonance (NMR) spectroscopy, Fourier-transform infrared (FT-IR) spectrometry, powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA), derivative thermogravimetry (DTG), and differential scanning calorimetry (DSC). The aqueous solubility and in vivo pharmacokinetic properties of the FAV-ILs were also evaluated. The FAV-ILs exhibited improved aqueous solubility by 78 to 125 orders of magnitude when compared with that of free FAV. Upon oral dosing in mice, the absolute bioavailability of the β-alanine ethyl ester FAV formulation was increased 1.9-fold compared with that of the control FAV formulation. The peak blood concentration, elimination half-life, and mean absorption time of FAV were also increased by 1.5-, 2.0-, and 1.5-fold, respectively, compared with the control. Furthermore, the FAV in the FAV-ILs exhibited significantly different biodistribution compared with the control FAV formulation. Interestingly, drug accumulation in the lungs and liver was improved 1.5-fold and 1.3-fold, respectively, compared with the control FAV formulation. These results indicate that the use of ILs exhibits potential as a simple, scalable strategy to improve the solubility and oral absorption of hydrophobic drugs, such as FAV.

Synthesis of ergosterol peroxide conjugates as mitochondria targeting probes for enhanced anticancer activity

Inspired by the significant bioactivity of ergosterol peroxide, we designed and synthesized four fluorescent coumarin and ergosterol peroxide conjugates 8a-d through the combination of ergosterol peroxide with 7-N,N-diethylamino coumarins fluorophore. The cytotoxicity of synthesized conjugates against three human cancer cells (HepG2, SK-Hep1, and MCF-7) was evaluated. The results of fluorescent imaging showed that the synthesized conjugates 8a-d localized and enriched mainly in mitochondria, leading to significantly enhanced cytotoxicity over ergosterol peroxide. Furthermore, the results of biological functions of 8d showed that it could suppress cell colony formation, invasion, and migration; induce G2/M phase arrest of HepG2 cells, and increase the intracellular ROS level.

Selective oxidation of amines to aldehydes or imines using laccase-mediated bio-oxidation

An efficient and practical chemo-enzymatic aerobic oxidation in water of benzylamines to obtain aldehydes or imines is described. Laccase from Trametes versicolor was chosen as biocatalyst, and TEMPO (radical 2,2,6,6-tetramethylpiperidine 1-oxyl) as mediator. A study on the pH dependence of the aqueous medium allowed us to realise a fine tuning on product selectivity. Under our optimized reaction conditions, the bio-oxidation of a series of primary, secondary and cyclic amines has been achieved.