N-(4-bromophenyl)-5-methyl-1-(4-methylbenzyl)-1H-pyrazole-3-carboxamide

Base Information

Chemical Name:N-(4-bromophenyl)-5-methyl-1-(4-methylbenzyl)-1H-pyrazole-3-carboxamide
CAS No.:353505-06-3
Molecular Formula:C₁₉H₁₈BrN₃O
Molecular Weight:384.275
Hs Code.:

Synonyms:N-(4-bromophenyl)-5-methyl-1-(4-methylbenzyl)-1H-pyrazole-3-carboxamide

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Chemical Property of N-(4-bromophenyl)-5-methyl-1-(4-methylbenzyl)-1H-pyrazole-3-carboxamide

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Technology Process of N-(4-bromophenyl)-5-methyl-1-(4-methylbenzyl)-1H-pyrazole-3-carboxamide

There total 5 articles about N-(4-bromophenyl)-5-methyl-1-(4-methylbenzyl)-1H-pyrazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 856905-30-1
5-methyl-1-(4-methylbenzyl)-1H-pyrazole-3-carboxylic acid

: 106-40-1
4-bromo-aniline

: 353505-06-3
N-(4-bromophenyl)-5-methyl-1-(4-methylbenzyl)-1H-pyrazole-3-carboxamide

Guidance literature:: 5-methyl-1-(4-methylbenzyl)-1H-pyrazole-3-carboxylic acid; With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

4-bromo-aniline; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1002/cmdc.201300357

Reference yield:

: 1085453-45-7
methyl 5-methyl-1-(4-methylbenzyl)-1H-pyrazole-3-carboxylate

: 353505-06-3
N-(4-bromophenyl)-5-methyl-1-(4-methylbenzyl)-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; sodium hydroxide / ethanol / 15 h / 70 °C

2.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 16 h / 20 °C

With water; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201300357

Reference yield:

: 20577-61-1
methyl 2,4-dioxopentanoate

: 353505-06-3
N-(4-bromophenyl)-5-methyl-1-(4-methylbenzyl)-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / 4 h / 90 °C

2.1: water; sodium hydroxide / ethanol / 15 h / 70 °C

3.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 16 h / 20 °C

With water; acetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201300357