N-n-propyl-N-<2-(2-methoxy-4-pyridyl)ethyl>-2-phenylethanamide

Base Information

• Chemical Name: N-n-propyl-N-<2-(2-methoxy-4-pyridyl)ethyl>-2-phenylethanamide
• CAS No.: 170026-06-9
• Molecular Formula: C₁₉H₂₄N₂O₂
• Molecular Weight: 312.412
• Mol file: 170026-06-9.mol

Synonyms:N-n-propyl-N-<2-(2-methoxy-4-pyridyl)ethyl>-2-phenylethanamide

Chemical Property of N-n-propyl-N-<2-(2-methoxy-4-pyridyl)ethyl>-2-phenylethanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-n-propyl-N-<2-(2-methoxy-4-pyridyl)ethyl>-2-phenylethanamide

There total 4 articles about N-n-propyl-N-<2-(2-methoxy-4-pyridyl)ethyl>-2-phenylethanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

N-n-propyl-2-(2-methoxy-4-pyridyl)ethylamine (773031-74-6) + phenylacetyl chloride (103-80-0) → N-n-propyl-N-<2-(2-methoxy-4-pyridyl)ethyl>-2-phenylethanamide (170026-06-9)

Guidance literature:

With triethylamine; In diethyl ether; for 12h; Ambient temperature;

DOI:10.1016/0223-5234(96)88251-1

Reference yield:

3-(2-methoxypyridin-4-yl)propanoic acid (102336-07-2) → N-n-propyl-N-<2-(2-methoxy-4-pyridyl)ethyl>-2-phenylethanamide (170026-06-9)

Guidance literature:

Multi-step reaction with 4 steps

1: conc. H₂SO₄, NaN₃ / 1.) 70 deg C, 2 h, 2.) RT, 12 h

2: 68 percent / Et₃N / tetrahydrofuran / 12 h / Ambient temperature

3: 1.) AcOH, NaBH₄ / 1.) dioxane, reflux, 4 h, 2.) CH₃OH, reflux, 12 h

4: 62 percent / Et₃N / diethyl ether / 12 h / Ambient temperature

With sodium tetrahydroborate; sodium azide; sulfuric acid; acetic acid; triethylamine; In tetrahydrofuran; diethyl ether;

DOI:10.1016/0223-5234(96)88251-1

Reference yield:

N-2-(2-methoxy-4-pyridyl)ethylpropanamide (170026-11-6) → N-n-propyl-N-<2-(2-methoxy-4-pyridyl)ethyl>-2-phenylethanamide (170026-06-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) AcOH, NaBH₄ / 1.) dioxane, reflux, 4 h, 2.) CH₃OH, reflux, 12 h

2: 62 percent / Et₃N / diethyl ether / 12 h / Ambient temperature

With sodium tetrahydroborate; acetic acid; triethylamine; In diethyl ether;

DOI:10.1016/0223-5234(96)88251-1

upstream raw materials:

N-n-propyl-2-(2-methoxy-4-pyridyl)ethylamine

phenylacetyl chloride

3-(2-methoxypyridin-4-yl)propanoic acid

N-2-(2-methoxy-4-pyridyl)ethylpropanamide

Downstream raw materials:

N-propyl-N-(2-phenylethyl)-2-(2-methoxy-4-pyridyl)ethylamine