(S)-N-((2-(2-fluoro-5-(2,2,2-trifluoroacetamido)phenyl)pent-4-en-2-yl)carbamothioyl)benzamide

Base Information

Chemical Name:(S)-N-((2-(2-fluoro-5-(2,2,2-trifluoroacetamido)phenyl)pent-4-en-2-yl)carbamothioyl)benzamide
CAS No.:1200497-18-2
Molecular Formula:C₂₁H₁₉F₄N₃O₂S
Molecular Weight:453.46
Hs Code.:

Synonyms:(S)-N-((2-(2-fluoro-5-(2,2,2-trifluoroacetamido)phenyl)pent-4-en-2-yl)carbamothioyl)benzamide

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Chemical Property of (S)-N-((2-(2-fluoro-5-(2,2,2-trifluoroacetamido)phenyl)pent-4-en-2-yl)carbamothioyl)benzamide

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Technology Process of (S)-N-((2-(2-fluoro-5-(2,2,2-trifluoroacetamido)phenyl)pent-4-en-2-yl)carbamothioyl)benzamide

There total 4 articles about (S)-N-((2-(2-fluoro-5-(2,2,2-trifluoroacetamido)phenyl)pent-4-en-2-yl)carbamothioyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1200497-16-0
(S)-N-(3-(2-aminopent-4-en-2-yl)-4-fluorophenyl)-2,2,2-trifluoroacetamide

: 532-55-8
Benzoyl isothiocyanate

: 1200497-18-2
(S)-N-((2-(2-fluoro-5-(2,2,2-trifluoroacetamido)phenyl)pent-4-en-2-yl)carbamothioyl)benzamide

Guidance literature:: In dichloromethane; at 20 ℃; for 0.833333h; Cooling with ice;

Reference yield:

: 1200497-14-8
N-(3-((S)-2-(((R)-tert-butylsulfinyl)amino)pent-4-en-2-yl)-4-fluorophenyl)-2,2,2-trifluoroacetamide

: 1200497-18-2
(S)-N-((2-(2-fluoro-5-(2,2,2-trifluoroacetamido)phenyl)pent-4-en-2-yl)carbamothioyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; ethanol / 1 h / 20 °C

1.2: pH 8 - 9

2.1: dichloromethane / 0.83 h / 20 °C / Cooling with ice

With hydrogenchloride; ethanol; In dichloromethane;

Reference yield:

: C₁₄H₁₆F₄N₂O₂S

: 1200497-18-2
(S)-N-((2-(2-fluoro-5-(2,2,2-trifluoroacetamido)phenyl)pent-4-en-2-yl)carbamothioyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: diethyl ether; tetrahydrofuran / 2 h / -78 °C

2.1: hydrogenchloride; ethanol / 1 h / 20 °C

2.2: pH 8 - 9

3.1: dichloromethane / 0.83 h / 20 °C / Cooling with ice

With hydrogenchloride; ethanol; In tetrahydrofuran; diethyl ether; dichloromethane;