[(R)-1-(4-chloro-2-fluorophenyl-3-boronic acid)propyl]carbamic acid tert-butyl ester

Base Information

Chemical Name:[(R)-1-(4-chloro-2-fluorophenyl-3-boronic acid)propyl]carbamic acid tert-butyl ester
CAS No.:1433402-42-6
Molecular Formula:C₁₄H₂₀BClFNO₄
Molecular Weight:331.58
Hs Code.:

Synonyms:[(R)-1-(4-chloro-2-fluorophenyl-3-boronic acid)propyl]carbamic acid tert-butyl ester

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Chemical Property of [(R)-1-(4-chloro-2-fluorophenyl-3-boronic acid)propyl]carbamic acid tert-butyl ester

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Technology Process of [(R)-1-(4-chloro-2-fluorophenyl-3-boronic acid)propyl]carbamic acid tert-butyl ester

There total 8 articles about [(R)-1-(4-chloro-2-fluorophenyl-3-boronic acid)propyl]carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1433402-34-6
{(R)-1-[4-chloro-2-fluoro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-propyl}-carbamic acid tert-butyl ester

: 1433402-42-6
[(R)-1-(4-chloro-2-fluorophenyl-3-boronic acid)propyl]carbamic acid tert-butyl ester

Guidance literature:: With sodium periodate; ammonium acetate; In water; acetone; at 20 ℃; for 2h;

Reference yield:

: 1433401-71-8
[(R)-1-(4-chloro-2-fluoro-phenyl)-propyl]-carbamic acid tert-butyl ester

: 1433402-42-6
[(R)-1-(4-chloro-2-fluorophenyl-3-boronic acid)propyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 15 h / -70 - -65 °C

1.2: 1.08 h / -65 °C

1.3: 3 h / -65 °C

2.1: ammonium acetate; sodium periodate / water; acetone / 2 h / 20 °C

With sodium periodate; n-butyllithium; ammonium acetate; In tetrahydrofuran; hexane; water; acetone;

Reference yield:

: 926664-60-0
(R)-(+)-2-methyl-propane-2-sulfinic acid (E)-1-(4-chloro-2-fluoro-phenyl)-methylideneamide

: 1433402-42-6
[(R)-1-(4-chloro-2-fluorophenyl-3-boronic acid)propyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran; diethyl ether / 3 h / -78 - -70 °C / Inert atmosphere; Large scale

1.2: 1.33 h / 20 °C / Inert atmosphere; Large scale

1.3: Heating; Large scale

2.1: sodium hydroxide / tetrahydrofuran / 1 h / 20 °C / Large scale

2.2: 20 °C / Large scale

3.1: n-butyllithium / tetrahydrofuran; hexane / 15 h / -70 - -65 °C

3.2: 1.08 h / -65 °C

3.3: 3 h / -65 °C

4.1: ammonium acetate; sodium periodate / water; acetone / 2 h / 20 °C

With sodium periodate; n-butyllithium; ammonium acetate; sodium hydroxide; In tetrahydrofuran; diethyl ether; hexane; water; acetone;