2-({2-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)benzamide

Base Information

• Chemical Name: 2-({2-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)benzamide
• CAS No.: 1086610-82-3
• Molecular Formula: C₂₀H₁₆ClN₅O₃S
• Molecular Weight: 441.898
• Mol file: 1086610-82-3.mol

Synonyms:2-({2-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)benzamide

Chemical Property of 2-({2-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-({2-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)benzamide

There total 3 articles about 2-({2-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2,4-dichloro-7-p-methylbenzenesulfonyl-7H-pyrrole[2,3-d]pyrimidin-4-amine (934524-10-4) + anthranilic acid amide (28144-70-9,88-68-6) → 2-({2-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)benzamide (1086610-82-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 85 ℃; for 8h;

DOI:10.1021/acsmedchemlett.9b00365

Reference yield:

2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine (90213-66-4) → 2-({2-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)benzamide (1086610-82-3)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutyl-ammonium chloride; sodium hydroxide / dichloromethane / 20 °C

2: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 8 h / 85 °C

With tetrabutyl-ammonium chloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In dichloromethane; isopropyl alcohol;

DOI:10.1021/acsmedchemlett.9b00365

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → 2-({2-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)benzamide (1086610-82-3)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutyl-ammonium chloride; sodium hydroxide / dichloromethane / 20 °C

2: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 8 h / 85 °C

With tetrabutyl-ammonium chloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In dichloromethane; isopropyl alcohol;

DOI:10.1021/acsmedchemlett.9b00365

upstream raw materials:

2,4-dichloro-7-p-methylbenzenesulfonyl-7H-pyrrole[2,3-d]pyrimidin-4-amine

anthranilic acid amide

2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine

p-toluenesulfonyl chloride

Downstream raw materials:

5-chloro-3-[(4-methylphenyl)sulfonyl]pyrrolo[2',3':4,5]pyrimido[6,1-b]quinazolin-7(3H)-one hydrochloride

2-[(7-[(4-methylphenyl)sulfonyl]-2-{[3,4,5-tris(methoxy)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]benzamide

N₂,N₂-dimethyl-N₁-[4-methyl-3-({3-[(4-methylphenyl)sulfonyl]-7-oxo-3,7-dihydropyrrolo[2',3':4,5]pyrimido[6,1-b]quinazolin-5-yl}amino)phenyl]glycinamide