1-Ethyl-3-methyl-6-(2-propoxy-5-aminophenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one

Base Information

• Chemical Name: 1-Ethyl-3-methyl-6-(2-propoxy-5-aminophenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one
• CAS No.: 168464-31-1
• Molecular Formula: C₁₇H₂₁N₅O₂
• Molecular Weight: 327.386
• Mol file: 168464-31-1.mol

Synonyms:1-Ethyl-3-methyl-6-(2-propoxy-5-aminophenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one

Chemical Property of 1-Ethyl-3-methyl-6-(2-propoxy-5-aminophenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Ethyl-3-methyl-6-(2-propoxy-5-aminophenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one

There total 8 articles about 1-Ethyl-3-methyl-6-(2-propoxy-5-aminophenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1-ethoxyethylidene)malononitrile (5417-82-3) → 1-Ethyl-3-methyl-6-(2-propoxy-5-aminophenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one (168464-31-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) CH₃ONa / 1.) CH₃OH, reflux, 15 min, 2.) CH₃OH, reflux, 2 h

2: pyridine / 3 h / 60 °C

3: aq. NaOH, 30percent H₂O₂ / 18 h / 100 °C

4: H₂ / 10percent Pd/C / ethanol / Ambient temperature

With pyridine; sodium hydroxide; hydrogen; dihydrogen peroxide; sodium methylate; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm950812j

Reference yield:

1-Ethyl-3-methyl-6-(2-propoxy 5-nitrophenyl)-1,5-dihydro-pyrazolo [3,4-d]pyrimidin-4-one (168464-25-3) → 1-Ethyl-3-methyl-6-(2-propoxy-5-aminophenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one (168464-31-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; Ambient temperature;

DOI:10.1021/jm950812j

Reference yield:

1,3-dimethyl-5-amino-1H-pyrazole-4-carbonitrile (54820-92-7) → 1-Ethyl-3-methyl-6-(2-propoxy-5-aminophenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one (168464-31-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 80 percent / conc. H₂SO₄ / 2 h / 60 °C

2: pyridine / Ambient temperature

3: 1 N NaOH / ethanol / 4 h / Heating

4: H₂ / 10percent Pd/C / ethanol / Ambient temperature

With pyridine; sodium hydroxide; sulfuric acid; hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm950812j

upstream raw materials:

1-Ethyl-3-methyl-6-(2-propoxy 5-nitrophenyl)-1,5-dihydro-pyrazolo [3,4-d]pyrimidin-4-one

1,3-dimethyl-5-amino-1H-pyrazole-4-carbonitrile

5-amino-1,3-dimethyl-1H-pyrazole-4-carboxamide

2-propoxy-5-nitrobenzoyl chloride