1-Ethyl-3-methyl-6-(2-propoxy 5-nitrophenyl)-1,5-dihydro-pyrazolo [3,4-d]pyrimidin-4-one

Base Information

• Chemical Name: 1-Ethyl-3-methyl-6-(2-propoxy 5-nitrophenyl)-1,5-dihydro-pyrazolo [3,4-d]pyrimidin-4-one
• CAS No.: 168464-25-3
• Molecular Formula: C₁₇H₁₉N₅O₄
• Molecular Weight: 357.369

Synonyms:1-Ethyl-3-methyl-6-(2-propoxy 5-nitrophenyl)-1,5-dihydro-pyrazolo [3,4-d]pyrimidin-4-one

Chemical Property of 1-Ethyl-3-methyl-6-(2-propoxy 5-nitrophenyl)-1,5-dihydro-pyrazolo [3,4-d]pyrimidin-4-one

Chemical Property:

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Technology Process of 1-Ethyl-3-methyl-6-(2-propoxy 5-nitrophenyl)-1,5-dihydro-pyrazolo [3,4-d]pyrimidin-4-one

There total 8 articles about 1-Ethyl-3-methyl-6-(2-propoxy 5-nitrophenyl)-1,5-dihydro-pyrazolo [3,4-d]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1-ethoxyethylidene)malononitrile (5417-82-3) → 1-Ethyl-3-methyl-6-(2-propoxy 5-nitrophenyl)-1,5-dihydro-pyrazolo [3,4-d]pyrimidin-4-one (168464-25-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) CH₃ONa / 1.) CH₃OH, reflux, 15 min, 2.) CH₃OH, reflux, 2 h

2: pyridine / 3 h / 60 °C

3: aq. NaOH, 30percent H₂O₂ / 18 h / 100 °C

With pyridine; sodium hydroxide; dihydrogen peroxide; sodium methylate;

DOI:10.1021/jm950812j

Reference yield:

N-(4-Cyano-2-ethyl-5-methyl-2H-pyrazol-3-yl)-5-nitro-2-propoxy-benzamide (1028303-96-9) → 1-Ethyl-3-methyl-6-(2-propoxy 5-nitrophenyl)-1,5-dihydro-pyrazolo [3,4-d]pyrimidin-4-one (168464-25-3)

Guidance literature:

With sodium hydroxide; dihydrogen peroxide; at 100 ℃; for 18h; Yield given;

DOI:10.1021/jm950812j

Reference yield:

1-Ethyl-3-methyl-5-(5-nitro-2-propoxy-benzoylamino)-1H-pyrazole-4-carboxylic acid amide → 1-Ethyl-3-methyl-6-(2-propoxy 5-nitrophenyl)-1,5-dihydro-pyrazolo [3,4-d]pyrimidin-4-one (168464-25-3)

Guidance literature:

With sodium hydroxide; In ethanol; for 4h; Yield given; Heating;

DOI:10.1021/jm950812j

upstream raw materials:

N-(4-Cyano-2-ethyl-5-methyl-2H-pyrazol-3-yl)-5-nitro-2-propoxy-benzamide

1,3-dimethyl-5-amino-1H-pyrazole-4-carbonitrile

5-amino-1,3-dimethyl-1H-pyrazole-4-carboxamide

2-propoxy-5-nitrobenzoyl chloride

Downstream raw materials:

1-Ethyl-3-methyl-6-(2-propoxy-5-aminophenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one

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