α-cyclopentyl<3,6-dimethoxy-2-(phenylethynyl)phenyl>methanol

Base Information

• Chemical Name: α-cyclopentyl<3,6-dimethoxy-2-(phenylethynyl)phenyl>methanol
• CAS No.: 153617-78-8
• Molecular Formula: C₂₂H₂₄O₃
• Molecular Weight: 336.431
• Mol file: 153617-78-8.mol

Synonyms:α-cyclopentyl<3,6-dimethoxy-2-(phenylethynyl)phenyl>methanol

Chemical Property of α-cyclopentyl<3,6-dimethoxy-2-(phenylethynyl)phenyl>methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-cyclopentyl<3,6-dimethoxy-2-(phenylethynyl)phenyl>methanol

There total 1 articles about α-cyclopentyl<3,6-dimethoxy-2-(phenylethynyl)phenyl>methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclopentanealdehyde (872-53-7) + 2-bromo-1,4-dimethoxy-3-(phenylethynyl)benzene (107135-56-8) → α-cyclopentyl<3,6-dimethoxy-2-(phenylethynyl)phenyl>methanol (153617-78-8)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1) hexane, ether, -78 deg C, 30 min, 2) hexane, ether, -78 to 0 deg C, 2 h;

DOI:10.1016/S0040-4020(01)88016-9

Reference yield: 85.0%

α-cyclopentyl<3,6-dimethoxy-2-(phenylethynyl)phenyl>methanol (153617-78-8) → <3,6-dimethoxy-2-(phenylethynyl)phenyl>methanone (153617-79-9)

Guidance literature:

With 3 A molecular sieve; pyridinium chlorochromate; In dichloromethane; for 6h; Ambient temperature;

DOI:10.1016/S0040-4020(01)88016-9

Reference yield:

α-cyclopentyl<3,6-dimethoxy-2-(phenylethynyl)phenyl>methanol (153617-78-8) → methoxy>trimethylsilane (153617-80-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / pyridinium chlorochromate, 3A mol. sieves / CH₂Cl₂ / 6 h / Ambient temperature

2: 92 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

With 3 A molecular sieve; triethylamine; pyridinium chlorochromate; In dichloromethane;

DOI:10.1016/S0040-4020(01)88016-9

upstream raw materials:

cyclopentanealdehyde

2-bromo-1,4-dimethoxy-3-(phenylethynyl)benzene

Downstream raw materials:

<3,6-dimethoxy-2-(phenylethynyl)phenyl>methanone

methoxy>trimethylsilane

<1-(phenylseleno)cyclopentyl><3,6-dimethoxy-2-(phenylethynyl)phenyl>methanone