1-o-tolylhept-1-yn-3-one

Base Information

Chemical Name:1-o-tolylhept-1-yn-3-one
CAS No.:1616859-83-6
Molecular Formula:C₁₄H₁₆O
Molecular Weight:200.28
Hs Code.:

Synonyms:1-o-tolylhept-1-yn-3-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-o-tolylhept-1-yn-3-one

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Technology Process of 1-o-tolylhept-1-yn-3-one

There total 2 articles about 1-o-tolylhept-1-yn-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 862250-84-8
1-(o-tolyl)-2-heptyn-1-one

: 1616859-83-6
1-o-tolylhept-1-yn-3-one

Guidance literature:: With silver tetrafluoroborate; tris(2,4-di-tert-butylphenyl)phosphite gold(I) chloride; In 1,2-dichloro-ethane; at 20 ℃; for 2h; regioselective reaction; Inert atmosphere; Schlenk technique; Glovebox;
DOI:10.1021/ja504892c

Reference yield:

: 933-88-0
ortho-toluoyl chloride

: 693-02-7
hex-1-yne

: 1616859-83-6
1-o-tolylhept-1-yn-3-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 0.08 h / 20 °C / Inert atmosphere; Schlenk technique; Glovebox

1.2: 20 °C / Inert atmosphere; Schlenk technique; Glovebox

2.1: tris(2,4-di-tert-butylphenyl)phosphite gold(I) chloride; silver tetrafluoroborate / 1,2-dichloro-ethane / 2 h / 20 °C / Inert atmosphere; Schlenk technique; Glovebox

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; silver tetrafluoroborate; tris(2,4-di-tert-butylphenyl)phosphite gold(I) chloride; triethylamine; In 1,2-dichloro-ethane;
DOI:10.1021/ja504892c

Reference yield: 82.0%

: 1616859-83-6
1-o-tolylhept-1-yn-3-one

: (E)-1-chloro-2-iodo-1-(o-tolyl)hept-1-en-3-one

Guidance literature:: With N-iodo-succinimide; acetic acid; lithium chloride; In dichloromethane; at 20 ℃; for 24h; regioselective reaction;
DOI:10.1016/j.chempr.2020.03.011