(S)-2-[(S)-3-(4-allyloxy-phenyl)-2-tert-butoxycarbonylamino-propionylamino]-4-methyl-pentanoic acid methyl ester

Base Information

• Chemical Name: (S)-2-[(S)-3-(4-allyloxy-phenyl)-2-tert-butoxycarbonylamino-propionylamino]-4-methyl-pentanoic acid methyl ester
• CAS No.: 145368-34-9
• Molecular Formula: C₂₄H₃₆N₂O₆
• Molecular Weight: 448.56

Synonyms:(S)-2-[(S)-3-(4-allyloxy-phenyl)-2-tert-butoxycarbonylamino-propionylamino]-4-methyl-pentanoic acid methyl ester

Chemical Property of (S)-2-[(S)-3-(4-allyloxy-phenyl)-2-tert-butoxycarbonylamino-propionylamino]-4-methyl-pentanoic acid methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of (S)-2-[(S)-3-(4-allyloxy-phenyl)-2-tert-butoxycarbonylamino-propionylamino]-4-methyl-pentanoic acid methyl ester

There total 2 articles about (S)-2-[(S)-3-(4-allyloxy-phenyl)-2-tert-butoxycarbonylamino-propionylamino]-4-methyl-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

methyl (L)-leucinate hydrochloride (7517-19-3) + N-(tert-butyloxycarbonyl)-O-allyl-(S)-tyrosine (127132-38-1) → (S)-2-[(S)-3-(4-allyloxy-phenyl)-2-tert-butoxycarbonylamino-propionylamino]-4-methyl-pentanoic acid methyl ester (145368-34-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1002/anie.200805014

Reference yield:

→ (S)-2-[(S)-3-(4-allyloxy-phenyl)-2-tert-butoxycarbonylamino-propionylamino]-4-methyl-pentanoic acid methyl ester (145368-34-9) + (2S)-3-[4-(allyloxy)phenyl]-2-[(tert-butoxycarbonyl)amino] propanoic acid

Guidance literature:

Reference yield: 100.0%

(S)-2-[(S)-3-(4-allyloxy-phenyl)-2-tert-butoxycarbonylamino-propionylamino]-4-methyl-pentanoic acid methyl ester (145368-34-9) → (S)-2-[(S)-3-(4-allyloxy-phenyl)-2-amino-propionylamino]-4-methyl-pentanoic acid methyl ester hydrogen chloride salt

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; at 20 ℃; for 18h;

upstream raw materials:

methyl (L)-leucinate hydrochloride

N-(tert-butyloxycarbonyl)-O-allyl-(S)-tyrosine

Downstream raw materials:

(S)-2-[(S)-3-(4-allyloxy-phenyl)-2-tert-butoxycarbonylamino-propionylamino]-4-methyl-pentanoic acid

2S-{2S-[3S-(4-allyloxyphenyl)-2-tert-butoxycarbonylaminopropionylamino]-4-methylpentanoylamino}-but-3-enoic acid methyl ester

2S-{2S-[3S-(4-allyloxyphenyl)-2-tert-butoxycarbonylaminopropionylamino]-4-methylpentanoylamino}-3-allylsulfanylpropionic acid methyl ester

(2S)-3-allyloxy-2-{(2S)-2-[(2S)-3-(4-allyloxyphenyl)-2-tert-butoxycarbonylaminopropionylamino]-4-methylpentanoylamino}propionic acid methyl ester

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