3,7-anhydro-4,5,6,8-tetra-O-benzyl-1,2-dideoxy-1-C-{8-[(trimethylsilyl)ethynyl]-9,10-anthraquinon-1-yl}-D-glycero-D-gulo-oct-1-ynitol

Base Information

Chemical Name:3,7-anhydro-4,5,6,8-tetra-O-benzyl-1,2-dideoxy-1-C-{8-[(trimethylsilyl)ethynyl]-9,10-anthraquinon-1-yl}-D-glycero-D-gulo-oct-1-ynitol
CAS No.:351032-75-2
Molecular Formula:C₅₅H₅₀O₇Si
Molecular Weight:851.083
Hs Code.:

Synonyms:3,7-anhydro-4,5,6,8-tetra-O-benzyl-1,2-dideoxy-1-C-{8-[(trimethylsilyl)ethynyl]-9,10-anthraquinon-1-yl}-D-glycero-D-gulo-oct-1-ynitol

Suppliers and Price of 3,7-anhydro-4,5,6,8-tetra-O-benzyl-1,2-dideoxy-1-C-{8-[(trimethylsilyl)ethynyl]-9,10-anthraquinon-1-yl}-D-glycero-D-gulo-oct-1-ynitol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3,7-anhydro-4,5,6,8-tetra-O-benzyl-1,2-dideoxy-1-C-{8-[(trimethylsilyl)ethynyl]-9,10-anthraquinon-1-yl}-D-glycero-D-gulo-oct-1-ynitol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3,7-anhydro-4,5,6,8-tetra-O-benzyl-1,2-dideoxy-1-C-{8-[(trimethylsilyl)ethynyl]-9,10-anthraquinon-1-yl}-D-glycero-D-gulo-oct-1-ynitol

There total 2 articles about 3,7-anhydro-4,5,6,8-tetra-O-benzyl-1,2-dideoxy-1-C-{8-[(trimethylsilyl)ethynyl]-9,10-anthraquinon-1-yl}-D-glycero-D-gulo-oct-1-ynitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 168253-07-4
(2R,3R,4R,5S,6S)-3,4,5-Tris-benzyloxy-2-benzyloxymethyl-6-ethynyl-tetrahydro-pyran

: 351032-68-3
1,8-bis[(trifluoromethyl)sulfonyloxy]-9,10-anthraquinone

: 1066-54-2
trimethylsilylacetylene

: 351032-70-7
1,8-bis[(trimethylsilyl)ethynyl]-9,10-anthraquinone

: 351032-75-2
3,7-anhydro-4,5,6,8-tetra-O-benzyl-1,2-dideoxy-1-C-{8-[(trimethylsilyl)ethynyl]-9,10-anthraquinon-1-yl}-D-glycero-D-gulo-oct-1-ynitol

Guidance literature:: (2R,3R,4R,5S,6S)-3,4,5-Tris-benzyloxy-2-benzyloxymethyl-6-ethynyl-tetrahydro-pyran; 1,8-bis[(trifluoromethyl)sulfonyloxy]-9,10-anthraquinone; With bis-triphenylphosphine-palladium(II) chloride; triethylamine; In N,N-dimethyl-formamide; at 80 - 85 ℃; for 1h;

trimethylsilylacetylene; With bis-triphenylphosphine-palladium(II) chloride; triethylamine; In N,N-dimethyl-formamide; at 80 - 85 ℃; for 2h;
DOI:10.1002/1522-2675(20010418)84:4<939::AID-HLCA939>3.0.CO;2-A

Reference yield:

: 117-10-2
1,8-dihydroxy-9,10-anthracenedione

: 351032-75-2
3,7-anhydro-4,5,6,8-tetra-O-benzyl-1,2-dideoxy-1-C-{8-[(trimethylsilyl)ethynyl]-9,10-anthraquinon-1-yl}-D-glycero-D-gulo-oct-1-ynitol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 76.5 percent / pyridine / 44 h / 0 °C

2.1: Pd(PPh₃)2Cl₂; Et₃N / dimethylformamide / 1 h / 80 - 85 °C

2.2: 33 percent / Pd(PPh₃)2Cl₂; Et₃N / dimethylformamide / 2 h / 80 - 85 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1002/1522-2675(20010418)84:4<939::AID-HLCA939>3.0.CO;2-A