2-(7-(3-ethyl-1H-1,2,4-triazol-1-yl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetic acid

Base Information

Chemical Name:2-(7-(3-ethyl-1H-1,2,4-triazol-1-yl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetic acid
CAS No.:701214-03-1
Molecular Formula:C₁₄H₁₃N₅O₄
Molecular Weight:315.288
Hs Code.:

Synonyms:2-(7-(3-ethyl-1H-1,2,4-triazol-1-yl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetic acid

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Chemical Property of 2-(7-(3-ethyl-1H-1,2,4-triazol-1-yl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetic acid

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Technology Process of 2-(7-(3-ethyl-1H-1,2,4-triazol-1-yl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetic acid

There total 1 articles about 2-(7-(3-ethyl-1H-1,2,4-triazol-1-yl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67443-38-3
5-bromo-2-chloro-3-nitropyridine

: 701214-03-1
2-(7-(3-ethyl-1H-1,2,4-triazol-1-yl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 1.5 h / -78 - -40 °C

2: sodium methylate; copper(I) bromide / 16 h / 110 - 120 °C / Sealed tube

3: potassium carbonate; copper / 52 h / Sealed tube; Heating

4: aluminum (III) chloride / dichloromethane; nitromethane / 1.5 h / 20 °C / Inert atmosphere

5: sodium hydroxide / methanol; water / 0.25 h / 20 °C

With aluminum (III) chloride; sodium methylate; copper; potassium carbonate; copper(I) bromide; sodium hydroxide; In tetrahydrofuran; methanol; nitromethane; dichloromethane; water; 4: |Friedel-Crafts Acylation;
DOI:10.1021/acs.jmedchem.8b00759

Reference yield: 82.0%

: 701214-03-1
2-(7-(3-ethyl-1H-1,2,4-triazol-1-yl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetic acid

: 56227-55-5,79332-89-1
N-benzoylpiperazine hydrochloride

: 701213-41-4
1-(4-benzoylpiperazin-1-yl)-2-(7-(3-ethyl-1H-1,2,4-triazol-1-yl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione

Guidance literature:: With dmap; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1021/acs.jmedchem.8b00759

Reference yield: 72.0%

: 619331-53-2
(R)-(2-methylpiperazin-1-yl)(phenyl)methanone

: 701214-03-1
2-(7-(3-ethyl-1H-1,2,4-triazol-1-yl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetic acid

: 701213-42-5
(R)-1-(4-benzoyl-3-methylpiperazin-1-yl)-2-(7-(3-ethyl-1H-1,2,4-triazol-1-yl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione

Guidance literature:: With dmap; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.8b00759