(R)-2-METHYL-1-BENZOYLPIPERAZINE

Base Information

• Chemical Name: (R)-2-METHYL-1-BENZOYLPIPERAZINE
• CAS No.: 619331-53-2
• Molecular Formula: C12H16N2O
• Molecular Weight: 204.27
• Mol file: 619331-53-2.mol

Synonyms:(R)-2-METHYL-1-BENZOYLPIPERAZINE;((R)-2-METHYLPIPERAZIN-1-YL)(PHENYL)METHANONE

Chemical Property of (R)-2-METHYL-1-BENZOYLPIPERAZINE

Chemical Property:

• Boiling Point: 345.3±35.0 °C(Predicted)
• PKA: 8.52±0.40(Predicted)
• PSA: 32.34000
• Density: 1.071±0.06 g/cm3(Predicted)
• LogP: 1.38720

Purity/Quality:

98%Min ^*data from raw suppliers

(R)-2-Methyl-1-benzoylpiperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-2-METHYL-1-BENZOYLPIPERAZINE

There total 1 articles about (R)-2-METHYL-1-BENZOYLPIPERAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (R)-(2-methylpiperazin-1-yl)(phenyl)methanone (619331-53-2)

Guidance literature:

Reference yield: 72.0%

(R)-(2-methylpiperazin-1-yl)(phenyl)methanone (619331-53-2) + 2-(7-(3-ethyl-1H-1,2,4-triazol-1-yl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetic acid (701214-03-1) → (R)-1-(4-benzoyl-3-methylpiperazin-1-yl)-2-(7-(3-ethyl-1H-1,2,4-triazol-1-yl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (701213-42-5)

Guidance literature:

With dmap; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.8b00759

Reference yield:

(R)-(2-methylpiperazin-1-yl)(phenyl)methanone (619331-53-2) + Z-L-Tyr-OH (1164-16-5) → C29H31N3O5 (1011469-64-9)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2007.11.077

Downstream raw materials:

C₁₉H₂₀N₄O₃S

C₂₉H₃₁N₃O₅

C₂₁H₁₉ClN₄O₃

(R)-1-(4-benzoyl-3-methylpiperazin-1-yl)-2-(7-chloro-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione